Antifungal Resistance in Candida auris: Molecular Determinants
| Autor: | Gustavo Acosta-Altamirano, Tania Vite-Garín, Rigoberto Hernández-Castro, Laura Rosio Castañón-Olivares, Alexandro Bonifaz, Roberto Arenas, Erick Martínez-Herrera, María Guadalupe Frías-De-León |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Candida auris 030106 microbiology Review Biology medicine.disease_cause Biochemistry Microbiology 03 medical and health sciences chemistry.chemical_compound Amphotericin B fluconazole medicine Pharmacology (medical) 5-fluorocytosine General Pharmacology Toxicology and Pharmaceutics caspofungin Gene Mutation Ergosterol lcsh:RM1-950 antifungal resistance amphotericin B 030104 developmental biology Infectious Diseases lcsh:Therapeutics. Pharmacology chemistry Efflux Caspofungin Fluconazole medicine.drug |
| Zdroj: | Antibiotics Antibiotics, Vol 9, Iss 568, p 568 (2020) |
| ISSN: | 2079-6382 |
| Popis: | Since Candida auris integrates strains resistant to multiple antifungals, research has been conducted focused on knowing which molecular mechanisms are involved. This review aims to summarize the results obtained in some of these studies. A search was carried out by consulting websites and online databases. The analysis indicates that most C. auris strains show higher resistance to fluconazole, followed by amphotericin B, and less resistance to 5-fluorocytosine and caspofungin. In C. auris, antifungal resistance to amphotericin B has been linked to an overexpression of several mutated ERG genes that lead to reduced ergosterol levels; fluconazole resistance is mostly explained by mutations identified in the ERG11 gene, as well as a higher number of copies of this gene and the overexpression of efflux pumps. For 5-fluorocytosine, it is hypothesized that the resistance is due to mutations in the FCY2, FCY1, and FUR1 genes. Resistance to caspofungin has been associated with a mutation in the FKS1 gene. Finally, resistance to each antifungal is closely related to the type of clade to which the strain belongs. |
| Databáze: | OpenAIRE |
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