Differentiation of Neuromyelitis Optica from Multiple Sclerosis on Spinal Magnetic Resonance Imaging
| Autor: | Bruce Schlakman, Joseph L. Gatlin, Majid Khan, Robert M. Herndon, Alan D. Penman, Saurabh Lalan |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Advanced and Specialized Nursing
medicine.medical_specialty Pathology Neuromyelitis optica Cord medicine.diagnostic_test business.industry Multiple sclerosis education Magnetic resonance imaging Articles medicine.disease Spinal cord Peripheral Lesion medicine.anatomical_structure Medicine Neurology (clinical) Radiology medicine.symptom business Spinal magnetic resonance imaging |
| Zdroj: | International Journal of MS Care. 14:209-214 |
| ISSN: | 1537-2073 |
| Popis: | In order to examine the accuracy of magnetic resonance imaging (MRI)–based diagnosis of neuromyelitis optica (NMO) versus multiple sclerosis (MS), we performed a retrospective, rater-blinded review of 29 cases of NMO and 30 cases of MS using the criteria of long (more than three vertebral levels), continuous lesions with a central cord location for NMO and more peripheral and patchy lesions for MS. Using these criteria, two raters were able to distinguish the two conditions with a good degree of confidence, particularly when the imaging was performed at the time of an acute cord attack. The sensitivity and specificity for diagnosis of NMO were 86.2% and 93.3%, respectively, for Rater A and 96.4% and 78.6%, respectively, for Rater B, with a kappa value of 0.72. Thus there are significant differences in lesion characteristics that allow the distinction on spinal cord imaging between MS and NMO with a moderately high degree of confidence. The location of the lesion as evident on MRI of the spine can be regarded as a distinguishing diagnostic feature between MS and NMO. |
| Databáze: | OpenAIRE |
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