Bioengineered Corneas Grafted as Alternatives to Human Donor Corneas in Three High‐Risk Patients

Autor: Oleksiy Buznyk, Stanislav Iakymenko, Per Fagerholm, Nataliya Pasyechnikova, Mohammad Mirazul Islam, May Griffith
Rok vydání: 2015
Předmět:
collagen
Graft Rejection
Male
Time Factors
medicine.medical_treatment
patients
Corneal Transplantation
Implants
Experimental
Annan medicinsk grundvetenskap
Tissue engineering
Risk Factors
Original Research Articles
General Pharmacology
Toxicology and Pharmaceutics
Other Basic Medicine
remodeling
Aged
80 and over
High risk patients
General Neuroscience
Endogenous regeneration
General Medicine
Transplant failure
Middle Aged
Tissue Donors
Eye Burns
Treatment Outcome
Female
medicine.medical_specialty
Prosthesis Design
General Biochemistry
Genetics and Molecular Biology
epithelium
grafting
transplantation
Burns
Chemical
medicine
Humans
Corneal Ulcer
Special Report
Vision
Ocular
Corneal transplantation
Aged
Tissue Engineering
Phosphorylcholine
business.industry
Recovery of Function
corneal ulcer
medicine.disease
eye diseases
Surgery
Transplantation
Special Reports
sense organs
business
Zdroj: Clinical and Translational Science
ISSN: 1752-8062
1752-8054
DOI: 10.1111/cts.12293
Popis: Corneas with severe pathologies have a high risk of rejection when conventionally grafted with human donor tissues. In this early observational study, we grafted bioengineered corneal implants made from recombinant human collagen and synthetic phosphorylcholine polymer into three patients for whom donor cornea transplantation carried a high risk of transplant failure. These patients suffered from corneal ulcers and recurrent erosions preoperatively. The implants provided relief from pain and discomfort, restored corneal integrity by promoting endogenous regeneration of corneal tissues, and improved vision in two of three patients. Such implants could in the future be alternatives to donor corneas for high-risk patients, and therefore, merits further testing in a clinical trial. Funding Agencies|Swedish Research Council (EU Nanomedicine project "I-CARE") [521-2012-5706]; Integrative Regenerative Medicine Centre, Linkoping, Sweden; Swedish Institute fellowship
Databáze: OpenAIRE
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