Generation of an induced pluripotent stem cell cohort suitable to investigate sporadic Alzheimer's Disease
| Autor: | Christian Weber, Maximilian Schieck, Yasmin Riesinger, David C. Schöndorf, Sara Kalman, Dagmar E. Ehrnhoefer, Ebru Ercan-Herbst, Myriam Elschami, Doris Steinemann |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Amyloid beta Induced Pluripotent Stem Cells Cell Culture Techniques Germ layer Disease Stem cell marker Cell Line 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Humans Dementia Induced pluripotent stem cell lcsh:QH301-705.5 Aged Aged 80 and over biology Cell Biology General Medicine Cortical neurons Middle Aged medicine.disease 030104 developmental biology lcsh:Biology (General) Cohort Cancer research biology.protein Female 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Stem Cell Research, Vol 34, Iss, Pp-(2019) |
| ISSN: | 1873-5061 |
| Popis: | Alzheimer's Disease (AD) is the major cause of dementia in the elderly, and cortical neurons differentiated from patient-derived induced pluripotent stem cells (iPSCs) can recapitulate disease phenotypes such as tau phosphorylation or amyloid beta (As) deposition. Here we describe the generation of an iPSC cohort consisting of 2 sporadic AD cases and 3 controls, derived from dermal fibroblasts. All lines were karyotypically normal, showed expression of stem cell markers and efficiently differentiated into cells of all three germ layers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|