The relationship between multiple myeloma and occupational exposure to six chlorinated solvents
| Autor: | Aaron Blair, Scott Davis, Mark P. Purdue, Noah S. Seixas, Kevin Milliken, Patricia A. Stewart, Anneclaire J. De Roos, Patricia Hartge, Laura S. Gold, Richard K. Severson |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Washington Michigan medicine.medical_specialty Trichloroethylene Low Confidence Cumulative Exposure Article Occupational medicine chemistry.chemical_compound Occupational Exposure Internal medicine Hydrocarbons Chlorinated Humans Medicine Multiple myeloma Aged business.industry Incidence (epidemiology) Public Health Environmental and Occupational Health Case-control study Middle Aged medicine.disease Surgery Occupational Diseases chemistry Solvents Female Solvent exposure Epidemiologic Methods Multiple Myeloma business |
| Zdroj: | Occupational and Environmental Medicine. 68:391-399 |
| ISSN: | 1351-0711 |
| DOI: | 10.1136/oem.2009.054809 |
| Popis: | Objectives Few studies have examined whether exposure to chlorinated solvents is associated with multiple myeloma. We evaluated associations between multiple myeloma and occupational exposure to six chlorinated solvents: 1,1,1-trichloroethane, trichloroethylene (TCE), methylene chloride (DCM), perchloroethylene, carbon tetrachloride and chloroform. Methods In-person interviews obtained occupational histories and information on jobs with likely solvent exposure. We assigned exposure metrics of probability, frequency, intensity and confidence using job-exposure matrices modified by job-specific questionnaire information. We used logistic regression to estimate ORs and 95% CIs for associations between multiple myeloma and ever exposure to each, and any, chlorinated solvent and analysed whether associations varied by duration and cumulative exposure. We also considered all occupations that were given the lowest confidence scores as unexposed and repeated all analyses. Results Risk of multiple myeloma was elevated for subjects ever exposed to 1,1,1-trichloroethane (OR (95% CI): 1.8 (1.1 to 2.9)). Ever exposure to TCE or DCM also entailed elevated, but not statistically significant, risks of multiple myeloma; these became statistically significant when occupations with low confidence scores were considered unexposed (TCE: 1.7 (1.0 to 2.7); DCM: 2.0 (1.2 to 3.2)). Increasing cumulative exposure to perchloroethylene was also associated with increasing multiple myeloma risk. We observed non-significantly increased multiple myeloma risks with exposure to chloroform; however, few subjects were exposed. Conclusions Evidence from this relatively large case-control study suggests that exposures to certain chlorinated solvents may be associated with increased incidence of multiple myeloma; however, the study is limited by relatively low participation (52%) among controls. |
| Databáze: | OpenAIRE |
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