Association Between Human Hair Loss and the Expression Levels of Nucleolin, Nucleophosmin, and UBTF Genes
| Autor: | Recep Eröz, Murat Kara, Sener Tasdemir, Haktan Bağış Erdem, Hasan Turkez, Ragip Ismail Engin, Hasan Dogan, Ibrahim Sahin |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Male Nucleolus Biology 03 medical and health sciences Gene expression medicine Humans Genetics (clinical) Nucleophosmin integumentary system Gene Expression Profiling Nuclear Proteins RNA-Binding Proteins Alopecia Antigens Nuclear General Medicine Middle Aged Hair follicle medicine.disease Phosphoproteins Molecular biology Gene expression profiling 030104 developmental biology medicine.anatomical_structure Hair loss Nucleolus organizer region Nucleolin Hair Follicle Pol1 Transcription Initiation Complex Proteins Cell Nucleolus |
| Zdroj: | Genetic testing and molecular biomarkers. 20(4) |
| ISSN: | 1945-0257 |
| Popis: | Dogan, Hasan/0000-0002-5232-4336 WOS: 000373932400008 PubMed: 26866305 Aims: Nucleolar organizer regions, also known as argyrophilic nucleolar organizer regions, are associated with ribosomal genes. The main function of the nucleolus is the rapid production of ribosomal subunits, a process that must be highly regulated to provide the appropriate levels for cellular proliferation and cell growth. There are no studies in the literature addressing the expression and function of nucleolar component proteins, including nucleophosmin, nucleolin and the upstream binding transcription factor (UBTF), in human follicular hair cells. Methods: Nineteen healthy males who had normal and sufficient hair follicles on the back of the head, but exhibited hair loss on the frontal/vertex portions of the head and 14 healthy males without hair loss were included in the current study. Gene expression levels were measured by relative quantitative real time polymerase chain reaction. Results: In the individuals suffering from alopecia, the total expression levels of nucleolin, nucleophosmin, and UBTF were lower in normal sites than in hair loss sites. Strong expression level correlations were detected between: nucleophosmin and nucleolin; nucleophosmin and UBTF, and nucleolin and UBTF for both groups. Conclusions: There was an association between human hair loss and the expression levels of nucleolin, nucleophosmin, and UBTF genes. Ataturk UniversityAtaturk University [2013/17] This work was supported by the research grants from Ataturk University (Project No. 2013/17). |
| Databáze: | OpenAIRE |
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