Plasma Fetuin-A Levels and the Risk of Myocardial Infarction and Ischemic Stroke
Autor: | Hans-Ulrich Häring, Cornelia Weikert, Matthias B. Schulze, Hans-Georg Joost, Tobias Pischon, Klaus Berger, Norbert Stefan, Heiner Boeing, Andreas Fritsche |
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Rok vydání: | 2008 |
Předmět: |
Risk
medicine.medical_specialty Population Myocardial Infarction Brain Ischemia Insulin resistance Predictive Value of Tests Physiology (medical) Internal medicine Humans Medicine Myocardial infarction Risk factor education Stroke education.field_of_study business.industry medicine.disease European Prospective Investigation into Cancer and Nutrition Endocrinology Cardiology alpha-Fetoproteins Metabolic syndrome Cardiology and Cardiovascular Medicine business alpha-2-HS-glycoprotein Follow-Up Studies |
Zdroj: | Circulation. 118:2555-2562 |
ISSN: | 1524-4539 0009-7322 |
Popis: | Background— Fetuin-A, a protein almost exclusively secreted by the liver, induces insulin resistance and subclinical inflammation in rodents. Circulating fetuin-A levels are elevated in humans with metabolic syndrome and insulin resistance, conditions that are associated with increased risk of cardiovascular disease. Methods and Results— We investigated the association between fetuin-A levels and the risk of future myocardial infarction (MI) and ischemic stroke (IS) in a case-cohort study based on the European Prospective Investigation into Cancer and Nutrition (EPIC)–Potsdam Study comprising 27 548 middle-aged subjects of the general population. Fetuin-A levels were measured in plasma of 227 individuals who developed MI, in 168 who developed IS, and in 2198 individuals who remained free of cardiovascular events during a mean follow-up of 8.2±2.2 years. Individuals in the highest compared with the lowest quintile of plasma fetuin-A had significantly increased risks of MI (relative risk, 3.80; 95% confidence interval, 2.37 to 6.10; P for trend P for trend P for trend P for trend Conclusions— Our data provide evidence for a link between high plasma fetuin-A levels and an increased risk of MI and IS. Therefore, more research is warranted to determine the role of fetuin-A in the pathophysiology of cardiovascular disease. |
Databáze: | OpenAIRE |
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