Bootcamp during Neoadjuvant Chemotherapy for Breast Cancer: A Randomized Pilot Trial
| Autor: | Veronica Cruz, Xian Jin Xie, Hong Zhao, David M. Euhus, Amy Harker-Murray, Roshni Rao, Barbara Haley, Yan Peng |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Improved survival lcsh:RC254-282 breast cancer Breast cancer Internal medicine medicine Stage (cooking) Original Research Chemotherapy exercise Tumor size biology business.industry Pilot trial Cancer medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Ki-67 biology.protein business neoadjuvant chemotherapy Biomedical engineering |
| Zdroj: | Breast Cancer: Basic and Clinical Research, Vol 6 (2012) Breast Cancer: Basic and Clinical Research, Vol 2012, Iss 6, Pp 39-46 (2012) Breast Cancer : Basic and Clinical Research |
| ISSN: | 1178-2234 |
| Popis: | Introduction Exercise may improve cancer outcomes. Neoadjuvant chemotherapy (NC) for breast cancer provides a unique setting to evaluate intervention effects. Treatments leading to decreased post-neoadjuvant Ki-67 levels, smaller tumor size, and higher pathologic response are associated with improved survival and lower recurrence. This randomized, prospective pilot trial evaluates the feasibility of supervised exercise during NC for breast cancer. Methods Stage II-III, ER positive, cancer patients with BMI > 25 receiving NC were randomized to standard NC with supervised bootcamp (NC + BC) or NC alone. Ki-67, C-peptide, BMI, and tumor size were measured before chemotherapy and at time of surgery. Results There were no initial differences between groups in regards to tumor size, C-peptide, BMI, and Ki-67. The NC + BC (n = 5) group had a lower mean BMI at the conclusion of NC compared with those (n = 5) in the NC group (28.0 versus 35.8, P = 0.03). Final tumor size was 2.59 cm in the NC + BC group versus 3.16 cm for NC ( P = 0.76) Mean Ki-67 for NC + BC was 7% versus 29% with NC ( P = 0.14). C-peptide (ng/mL) was equivalent between the two groups (4.55 NC + BC versus 4.74 NC, P = 0.85). Conclusions Adding a supervised exercise program to NC is feasible, decreases BMI, and may lead to lower Ki-67 levels and improved survival. |
| Databáze: | OpenAIRE |
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