Visual hemineglect induced by unilateral striatal dopamine deficiency in monkeys
Autor: | Okihide Hikosaka, Makoto Kato, Nobuo Miyashita |
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Rok vydání: | 1995 |
Předmět: |
Male
Eye Movements Tyrosine 3-Monooxygenase Dopamine Central nervous system Caudate nucleus Striatum chemistry.chemical_compound Basal ganglia Saccades medicine Animals Neurotransmitter General Neuroscience MPTP Dopaminergic Immunohistochemistry Corpus Striatum medicine.anatomical_structure chemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Visual Perception Macaca Psychology Neuroscience medicine.drug |
Zdroj: | NeuroReport. 6:1257-1260 |
ISSN: | 0959-4965 |
Popis: | Unilateral dopamine deficiency of the basal ganglia produced a profound impairment of visual search. Dopaminergic innervation of the monkey striatum was deprived unilaterally by infusing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the caudate nucleus. The monkeys were shown a mirror in which they saw their own image and surroundings. Compared with the concentric and symmetrical distribution of visual search before MPTP infusion, the gaze after MPTP infusion was confined and sometimes frozen in peripheral regions in the hemispace ipsilateral to the infusion; the contralateral side was largely neglected. An experiment using a choice saccade task indicated that the contralateral visual signal, which alone was processed normally, was suppressed by the ipsilateral signal. |
Databáze: | OpenAIRE |
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