Overnight Levels of Luteinizing Hormone, Follicle-Stimulating Hormone and Growth Hormone before and during Gonadotropin-Releasing Hormone Analogue Treatment in Short Boys Born Small for Gestational Age
| Autor: | R. J. Odink, Frank H. de Jong, Susan R. Rose, Willie M. Bakker van Waarde, Anita C. S. Hokken-Koelega, Danielle C. M. van der Kaay, Eric J. Sulkers |
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| Přispěvatelé: | Pediatrics, Internal Medicine |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Male
Gonadotropin-releasing hormone analogue treatment PREPUBERTAL CHILDREN CENTRAL PRECOCIOUS PUBERTY Follicle-stimulating hormone levels Endocrinology Diabetes and Metabolism medicine.medical_treatment Puberty Precocious Growth hormone Follicle-stimulating hormone Endocrinology AGONIST TREATMENT Insulin-Like Growth Factor I Child Growth Disorders BINDING PROTEIN-3 Human Growth Hormone Small for gestational age Luteinizing hormone levels Infant Small for Gestational Age medicine.symptom Luteinizing hormone endocrine system medicine.medical_specialty Growth hormone levels Treatment results Short stature URINARY GH EXCRETION Internal medicine medicine Humans SHORT STATURE Gonadotropin-releasing hormone analogue I IGF-I business.industry INTRAUTERINE GROWTH Infant Newborn Luteinizing Hormone medicine.disease Body Height LEUPROLIDE ACETATE Insulin-Like Growth Factor Binding Protein 3 Pediatrics Perinatology and Child Health SECRETORY DYNAMICS Follicle Stimulating Hormone Leuprolide business Hormone |
| Zdroj: | HORMONE RESEARCH, 71(5), 260-267 Hormone Research, 71, 260-267. Karger |
| ISSN: | 0301-0163 |
| Popis: | Aims: To evaluate if 3 months of gonadotropin-releasing hormone analogue (GnRHa) treatment results in sufficient suppression of pubertal luteinizing hormone (LH) and follicle-stimulating hormone (FSH) profile patterns in short pubertal small for gestational age (SGA) boys. To compare growth hormone (GH) profiles and fasting insulin-like growth factor (IGF)-I and IGF-binding protein-3 (IGFBP-3) levels after 3 months of GnRHa treatment with those at baseline. Methods: After measurement of baseline overnight profiles and IGF-I and IGFBP-3 levels, 14 short pubertal SGA boys received leuprorelide acetate depots of 3.75 mg subcutaneously, every 4 weeks. Results: At baseline, mean GH levels were comparable with those of controls, whereas IGF-I and IGFBP-3 standard deviation scores (SDS) were significantly lower than zero SDS. After 3 months of GnRHa treatment, all boys showed clinical arrest of puberty. The area under the curve above zero, mean and maximum LH and FSH had significantly decreased to prepubertal levels. Peak LH during the GnRH agonist test, however, indicated insufficient pubertal suppression in 43% of boys. Overnight GH profile characteristics and IGF-I and IGFBP-3 levels did not significantly change. Conclusions: Puberty was sufficiently suppressed by GnRHa treatment, as shown by the prepubertal LH and FSH profiles. After 3 months of GnRHa treatment, overnight GH profile characteristics had not significantly changed, reflecting that GH levels are comparable for prepubertal and early pubertal boys. |
| Databáze: | OpenAIRE |
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