Direct, Metal-Free Amination of Heterocyclic Amides/Ureas with NH-Heterocycles and N-Substituted Anilines in POCl3

Autor:	Roger Faessler, Armin Roessler, Xiaohu Deng, Ivana Brdar, Neelakandha S. Mani, Zachary S. Sales, Jiejun Wu
Rok vydání:	2011
Předmět:	Prescription Drugs Chemistry Pharmaceutical Catalysis Piperazines Rosiglitazone Erlotinib Hydrochloride Heterocyclic Compounds Humans Hypnotics and Sedatives Hypoglycemic Agents Urea Organic chemistry Rosuvastatin Calcium Eszopiclone Protein Kinase Inhibitors Amination Reaction conditions Sulfonamides Aniline Compounds Molecular Structure Chemistry Anticholesteremic Agents Organic Chemistry Hydrogen-Ion Concentration Phosphorus Compounds Amides Fluorobenzenes Pyrimidines Metal free Benzamides Imatinib Mesylate Quinazolines Thiazolidinediones Azabicyclo Compounds
Zdroj:	The Journal of Organic Chemistry. 76:8262-8269
ISSN:	1520-6904 0022-3263
DOI:	10.1021/jo201425q
Popis:	A POCl(3)-mediated, direct amination reaction of heterocyclic amides/ureas with NH-heterocycles or N-substituted anilines is described. Compared to the existing methods, this operationally simple protocol provides unique reactivity and functional group compatibility because of the metal-free, acidic reaction conditions. The yields are generally excellent.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9502b07263333af0badef9203bcfa7ca https://doi.org/10.1021/jo201425q Zobrazit plný text záznamu