Potential role of the intestinal microbiota of the mother in neonatal immune education
| Autor: | Iris Segura-Roggero, Jalil Benyacoub, Eduardo Schiffrin, Pablo Perez, Joël Doré, Marion Leclerc, Patrick Serrant, Florence Levenez, Anne Donnet-Hughes |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Breast milk Mammary gland Medicine (miscellaneous) Biology Peripheral blood mononuclear cell Mice Immune system Intestinal mucosa Cell Movement Pregnancy Lactation medicine Animals Humans Mesenteric lymph nodes Intestinal Mucosa Ciencias Exactas Nutrition and Dietetics Bacteria Milk Human Microbiota Neonatal immunity Infant Newborn Dendritic Cells Mice Inbred C57BL Blood Breast Feeding medicine.anatomical_structure Lymphatic system Bacterial translocation Bacterial Translocation Immune System Immunology Leukocytes Mononuclear Female Lymph Breast feeding |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| Popis: | Mucosal dendritic cells are at the heart of decision-making processes that dictate immune reactivity to intestinal microbes. They ensure tolerance to commensal bacteria and a vigorous immune response to pathogens. It has recently been demonstrated that the former involves a limited migration of bacterially loaded dendritic cells from the Peyer's patches to the mesenteric lymph nodes. During lactation, cells from gut-associated lymphoid tissue travel to the breast via the lymphatics and peripheral blood. Here, we show that human peripheral blood mononuclear cells and breast milk cells contain bacteria and their genetic material during lactation. Furthermore, we show an increased bacterial translocation from the mouse gut during pregnancy and lactation and the presence of bacterially loaded dendritic cells in lactating breast tissue. Our observations show bacterial translocation as a unique physiological event, which is increased during pregnancy and lactation. They suggest endogenous transport of intestinally derived bacterial components within dendritic cells destined for the lactating mammary gland. They also suggest neonatal immune imprinting by milk cells containing commensal-associated molecular patterns. Facultad de Ciencias Exactas |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|