Histopathology, vitellogenin and chemical body burden in mosquitofish (Gambusia holbrooki) sampled from six river sites receiving a gradient of stressors
| Autor: | Louis A. Tremblay, Richard P. Lim, Peta A. Neale, Julie Mondon, Frederic D.L. Leusch, Heather M. Coleman, Michael St. J. Warne, Philip D. Scott, Stuart J. Khan, Erik Prochazka, James A. McDonald |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Environmental Engineering
Zoology 010501 environmental sciences Biology Endocrine Disruptors 01 natural sciences Gambusia Vitellogenin Cyprinodontiformes Vitellogenins Environmental Chemistry Bioassay Endocrine system Animals 14. Life underwater Waste Management and Disposal 0105 earth and related environmental sciences Pollutant 010401 analytical chemistry Contamination Pesticide biology.organism_classification Pollution 6. Clean water 0104 chemical sciences 13. Climate action Environmental chemistry biology.protein Body Burden Queensland Mosquitofish Environmental Sciences Water Pollutants Chemical Environmental Monitoring |
| Popis: | © 2017 Elsevier B.V. There are over 40,000 chemical compounds registered for use in Australia, and only a handful are monitored in the aquatic receiving environments. Their effects on fish species in Australia are largely unknown. Mosquitofish (Gambusia holbrooki) were sampled from six river sites in Southeast Queensland identified as at risk from a range of pollutants. The sites selected were downstream of a wastewater treatment plant discharge, a landfill, two agricultural areas, and two sites in undeveloped reaches within or downstream of protected lands (national parks). Vitellogenin analysis, histopathology of liver, kidney and gonads, morphology of the gonopodium, and chemical body burden were measured to characterize fish health. Concentrations of trace organic contaminants (TrOCs) in water were analyzed by in vitro bioassays and chemical analysis. Estrogenic, anti-estrogenic, anti-androgenic, progestagenic and anti-progestagenic activities and TrOCs were detected in multiple water samples. Several active pharmaceutical ingredients (APIs), industrial compounds, pesticides and other endocrine active compounds were detected in fish carcasses at all sites, ranging from < 4–4700 ng/g wet weight, including the two undeveloped sites. While vitellogenin protein was slightly increased in fish from two of the six sites, the presence of micropollutants did not cause overt sexual endocrine disruption in mosquitofish (i.e., no abnormal gonads or gonopodia). A correlation between lipid accumulation in the liver with total body burden warrants further investigation to determine if exposure to low concentrations of TrOCs can affect fish health and increase stress on organs such as the liver and kidneys via other mechanisms, including disruption of non-sexual endocrine axes involved in lipid regulation and metabolism. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|