Endorectal Brachytherapy Boost After External Beam Radiation Therapy in Elderly or Medically Inoperable Patients With Rectal Cancer : Primary Outcomes of the Phase 1 HERBERT Study

Autor: L.A. Velema, Jan-Huib Franssen, Jeroen Buijsen, E.C. Rijkmans, Remi A. Nout, M. Ketelaars, Tom Rozema, Desirée H.J.G. van den Bongard, Annemieke Cats, Corrie A.M. Marijnen, Baukelien van Triest
Přispěvatelé: RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy, Radiotherapie, Academic Medical Center
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
Cancer Research
Colorectal cancer
medicine.medical_treatment
Brachytherapy
030218 nuclear medicine & medical imaging
ENDOCAVITARY
0302 clinical medicine
CONTACT RADIOTHERAPY
Aged
80 and over
Radiation
Middle Aged
Clinical Trial
Treatment Outcome
Oncology
Radiology Nuclear Medicine and imaging
030220 oncology & carcinogenesis
Toxicity
INTEGRATED-BOOST
Female
Radiology
TOMOTHERAPY
ORGAN PRESERVATION
medicine.medical_specialty
Maximum Tolerated Dose
Frail Elderly
Tomotherapy
Disease-Free Survival
CHEMORADIOTHERAPY
Clinical Trial
Phase I
03 medical and health sciences
Phase I
NEOADJUVANT CHEMORADIATION
medicine
Journal Article
Humans
Radiology
Nuclear Medicine and imaging
Proctitis
Aged
business.industry
Rectal Neoplasms
Dose fractionation
COMPLETE CLINICAL-RESPONSE
ADENOCARCINOMA
medicine.disease
Clinical trial
EXPERIENCE
Dose Fractionation
Radiation
business
Nuclear medicine
Chemoradiotherapy
Zdroj: International Journal of Radiation Oncology Biology Physics, 98(4), 908. Elsevier Inc.
International Journal of Radiation Oncology Biology Physics, 98(4), 908-917. Elsevier Science
International Journal of Radiation Oncology Biology Physics, 98(4), 908-917. Elsevier Inc.
International Journal of Radiation Oncology-Biology-Physics, 98(4), 908-917
ISSN: 0360-3016
Popis: Purpose To evaluate the toxicity and efficacy of the combination of external beam radiation therapy (EBRT) followed by high-dose-rate endorectal brachytherapy (HDREBT) boost in elderly and medically inoperable patients with rectal cancer. Methods and Materials A phase 1 dose-escalation study was performed. Treatment consisted of EBRT (13 × 3 Gy) followed by 3 weekly brachytherapy applications 6 weeks later. The HDREBT dose started at 5 Gy per fraction, increasing with 1 Gy per fraction if dose-limiting toxicity (DLT, defined as grade ≥3 proctitis
Databáze: OpenAIRE
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