Effects of long-term intake of a yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 on mice
| Autor: | Hiroko Ohmiya, Seiya Imoto, Satoshi Uematsu, Naoki Takemura, Yasuo Ouchi, Hiromi Suzuki, Satoko Hagiwara, Yukio Asami, Satomi Koyama, Kosuke Fujimoto, Yasumasa Kimura, Hirotoshi Tanaka, Kyosuke Kobayashi, Yuki Usui, Takeshi Satoh, Gérard Eberl |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Streptococcus thermophilus Firmicutes 030106 microbiology Immunology Antimicrobial peptides Butyrate Mice 03 medical and health sciences Lactobacillus Animals Immunology and Allergy Food science Lactobacillus delbrueckii Mice Inbred ICR biology Probiotics food and beverages Bacteroidetes General Medicine Yogurt biology.organism_classification Intestines 030104 developmental biology Fermentation Lactobacillus delbrueckii subsp. bulgaricus |
| Zdroj: | International Immunology. 30:319-331 |
| ISSN: | 1460-2377 0953-8178 |
| DOI: | 10.1093/intimm/dxy035 |
| Popis: | The gut is an extremely complicated ecosystem where micro-organisms, nutrients and host cells interact vigorously. Although the function of the intestine and its barrier system weakens with age, some probiotics can potentially prevent age-related intestinal dysfunction. Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131, which are the constituents of LB81 yogurt, are representative probiotics. However, it is unclear whether their long-term intake has a beneficial influence on systemic function. Here, we examined the gut microbiome, fecal metabolites and gene expression profiles of various organs in mice. Although age-related alterations were apparent in them, long-term LB81 yogurt intake led to an increased Bacteroidetes to Firmicutes ratio and elevated abundance of the bacterial family S24-7 (Bacteroidetes), which is known to be associated with butyrate and propanoate production. According to our fecal metabolite analysis to detect enrichment, long-term LB81 yogurt intake altered the intestinal metabolic pathways associated with propanoate and butanoate in the mice. Gene ontology analysis also revealed that long-term LB81 yogurt intake influenced many physiological functions related to the defense response. The profiles of various genes associated with antimicrobial peptides-, tight junctions-, adherens junctions- and mucus-associated intestinal barrier functions were also drastically altered in the LB81 yogurt-fed mice. Thus, long-term intake of LB81 yogurt has the potential to maintain systemic homeostasis, such as the gut barrier function, by controlling the intestinal microbiome and its metabolites. |
| Databáze: | OpenAIRE |
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