Changes in bone mass associated with obesity and weight loss in humans: Applicability of animal models
| Autor: | Vivi F.H. Jensen, Anne-Marie Mølck, Majken Dalgaard, Kristina Åkesson, Fiona E. McGuigan |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Histology Physiology Endocrinology Diabetes and Metabolism Human bone 030209 endocrinology & metabolism Bone and Bones 03 medical and health sciences 0302 clinical medicine Animal model Bone Density Weight loss Weight Loss medicine Animals Humans Obesity business.industry Nutritional status medicine.disease Menopause 030104 developmental biology Models Animal medicine.symptom business Bone mass |
| Zdroj: | Bone. 145:115781 |
| ISSN: | 8756-3282 |
| Popis: | The implications of obesity and weight loss for human bone health are not well understood. Although the bone changes associated with weight loss are similar in humans and rodents, that is not the case for obesity. In humans, obesity is generally associated with increased bone mass, an outcome which is exacerbated by advanced age and menopause. In rodents, by contrast, bone mass decreases in proportion to severity and duration of obesity, and is influenced by sex, age and mechanical load. Despite these discrepancies, rodents are frequently used to model the situation in humans. In this review, we summarise the existing knowledge of the effects of obesity and weight loss on bone mass in humans and rodents, focusing on the translatability of findings from animal models. We then describe how animal models should be used to broaden the understanding of the relationship between obesity, weight loss, and skeletal health in humans. Specifically, we highlight the aspects of study design that should be considered to optimise translatability of the rodent models of obesity and weight loss. Notably, the sex, age, and nutritional status of the animals should ideally match those of interest in humans. With these caveats in mind, and depending on the research question asked, our review underscores that animal models can provide valuable information for obesity and weight-management research. |
| Databáze: | OpenAIRE |
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