Autocrine activation of platelet-derived growth factor receptor α in metastatic papillary thyroid cancer
| Autor: | Mireille M. Kattar, Esther Ekpe Adewuyi, Jean Deschenes, Todd P. W. McMullen, Sunita Ghosh, Ana Lopez-Campistrous |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Receptor Platelet-Derived Growth Factor alpha medicine.medical_treatment Pathology and Forensic Medicine Papillary thyroid cancer Thyroid carcinoma 03 medical and health sciences 0302 clinical medicine medicine Biomarkers Tumor Humans Thyroid Neoplasms Autocrine signalling Aged Platelet-Derived Growth Factor Oncogene biology business.industry Growth factor Thyroid Middle Aged medicine.disease 3. Good health Autocrine Communication 030104 developmental biology medicine.anatomical_structure Thyroid Cancer Papillary 030220 oncology & carcinogenesis Lymphatic Metastasis biology.protein Cancer research Immunohistochemistry Female business Platelet-derived growth factor receptor |
| Zdroj: | Human pathology. 75 |
| ISSN: | 1532-8392 |
| Popis: | Metastatic dissemination of papillary thyroid cancer has been reported to be strongly associated with expression of platelet-derived growth factor (PDGFR) α and altered TTF1 function. However, the status of PDGF ligands in papillary thyroid cancer and the potential role of these ligands in metastatic disease are obscure. We assessed the prevalence of PDGF ligands in benign and malignant thyroid tumors to determine if ligand upregulation is associated with α-isoform (PDGF-AA or PDGF-BB) or the β-isoform (PDGF-BB or PDGF-DD) of PDGFR in individual tumors. The immunohistochemical expression of PDGFRα, PDGF-AA, PDGF-BB, and PDGF-DD was surveyed in follicular adenomas (n=55), papillary thyroid carcinomas (103 with and 59 without nodal metastases), and lymph node metastasis (n=12). There is an augmented tendency for PDGF-AA expression in node-positive papillary thyroid cancer metastases (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect