Evidence that nerve growth factor mediates the formation of sensory pericellular baskets in the rat trigeminal ganglion
| Autor: | Lori G. Isaacson, S.E. Shoemaker |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
animal structures medicine.medical_treatment Calcitonin Gene-Related Peptide Neuropeptide Sensory system Cytochrome c Group Superior Cervical Ganglion Biology Calcitonin gene-related peptide Rats Sprague-Dawley Trigeminal ganglion Internal medicine Nerve Growth Factor medicine Animals Injections Intraventricular Neurons Neuronal Plasticity General Neuroscience Dendrites Immunohistochemistry Ganglionectomy Ganglion Rats medicine.anatomical_structure Endocrinology Nerve growth factor nervous system Sympathectomy Trigeminal Ganglion embryonic structures Cervical ganglia Female Neuroscience |
| Zdroj: | Neuroscience letters. 331(3) |
| ISSN: | 0304-3940 |
| Popis: | A role for nerve growth factor (NGF) in the remodeling of sensory neurons in the trigeminal ganglion was examined. Intracerebroventricular NGF infusion and/or bilateral removal of the sympathetic superior cervical ganglia, both of which are believed to increase the availability of NGF to primary sensory neurons, resulted in a significant increase in the frequency of calcitonin gene-related peptide immunoreactive pericellular baskets. The results of this study suggest that increased NGF is sufficient to enhance the formation of sensory baskets in this ganglion, and provide evidence that NGF may mediate the formation of sensory baskets in the sensory ganglia following injury. |
| Databáze: | OpenAIRE |
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