In vivo effects of thymustimulin on hematopoiesis of mice treated with cyclophosphamide
| Autor: | Riccardo Ghio, Silvana Timitilli, Enrico Balleari, Alessandra Battaglia, Cristina Musselii, Massa G |
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| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Cyclophosphamide Ratón Immunology Spleen Biology Thymus Extracts Pathology and Forensic Medicine Mice In vivo Internal medicine medicine Immunology and Allergy Animals Mice Inbred C3H Biological activity bacterial infections and mycoses In vitro Hematopoiesis Haematopoiesis Endocrinology medicine.anatomical_structure Female Bone marrow medicine.drug |
| Zdroj: | Clinical immunology and immunopathology. 68(3) |
| ISSN: | 0090-1229 |
| Popis: | This study reports on the in vivo effects of thymustimulin (TST), a thymic extract, on the hematopoiesis of mice treated with cyclophosphamide (CTX). Peripheral blood counts and both bone marrow pluripotent (spleen colonyforming units, CFU-S) and committed (granulocyte-macrophage colony-forming units, CFU-GM; erythroid burst-forming units, BFU-E) hematopoietic progenitor cells were assayed by in vitro methods. Administration of CTX alone was associated with severe hemotoxicity, which was followed by a gradual recovery of hematopoiesis. Hematotoxic effect of CTX was less pronounced when TST was administered in association with CTX. All the studied parameters were higher in TST + CTX-treated animals than those in CTX-treated animals, especially after Day 5 from the beginning of treatment for blood leukocytes, bone marrow cell counts, and packed red cell volume, and at Day 10 or 15 for CFU-S, CFU-GM, and BFU-E. These findings suggest that, in this experimental model, the simultaneous administration of TST reduces the myelosuppressive activity of CTX in vivo. |
| Databáze: | OpenAIRE |
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