Effect of n-3 polyunsaturated fatty acid intake on phospholipid fatty acid composition in plasma and erythrocytes
| Autor: | Domenico Prisco, Rita Paniccia, Isa Francalanci, M. Filippini, Gian Franco Gensini, K Abbate, G.G. Neri Serneri |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Erythrocytes Docosahexaenoic Acids Phospholipid Administration Oral Medicine (miscellaneous) Phosphatidylserines Phosphatidylinositols chemistry.chemical_compound Fatty Acids Omega-3 medicine Humans Food science Phospholipids chemistry.chemical_classification Nutrition and Dietetics Fatty Acids Fatty acid Washout Eicosapentaenoic acid Red blood cell medicine.anatomical_structure Eicosapentaenoic Acid chemistry Biochemistry Docosahexaenoic acid Fatty Acids Unsaturated Phosphatidylcholines lipids (amino acids peptides and proteins) Olive oil Polyunsaturated fatty acid |
| Zdroj: | The American Journal of Clinical Nutrition. 63:925-932 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/63.6.925 |
| Popis: | To characterize the time course of plasma and red blood cell (RBC) changes after n-3 polyunsaturated fatty acid (PUFA) supplementation, 20 healthy male volunteers were randomly assigned to receive either four 1-g capsules of n-3 PUFA ethyl esters or four 1-g capsules of olive oil (as placebo) for a period of 4 mo, followed by a 3-mo washout period. Fatty acids of plasma and RBC phospholipid fractions were analyzed at 0, 2, and 4 mo of treatment and at 1, 2, and 3 mo of washout. During n-3 PUFA supplementation, accumulations of eicosapentaenoic (EPA), docosapentaenoic (DPA), and docosahexaenoic (DHA) acids were marked after 2 mo with differences among different fractions of plasma and RBCs in further accumulation up to 4 mo. During the first and second months of the washout, slight differences were observed in changes of various fatty acids among different phospholipid fractions, but after 3 mo of washout, only minor alterations were still detectable with respect to pretreatment values. These data confirm the complex relations among different fatty acid pools after n-3 PUFA supplementation. |
| Databáze: | OpenAIRE |
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