Cancer and risk of Alzheimer’s disease: Small association in a nationwide cohort study

Autor: Mikael Rørth, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Katalin Veres, Anne Gulbech Ording, Victor W. Henderson, M. Maria Glymour
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
Epidemiology
Denmark
neoplasms
Disease
0302 clinical medicine
Cancer Survivors
Neoplasms
030212 general & internal medicine
Registries
Child
risk
Aged
80 and over

education.field_of_study
Health Policy
Incidence
Alzheimer's disease
Middle Aged
Survival Rate
Psychiatry and Mental health
Child
Preschool

epidemiology
Female
Cohort study
Adult
Risk
medicine.medical_specialty
Adolescent
Population
Article
03 medical and health sciences
Cellular and Molecular Neuroscience
Young Adult
Developmental Neuroscience
Alzheimer Disease
Internal medicine
medicine
Humans
education
Aged
business.industry
Infant
Newborn

Cancer
Infant
medicine.disease
Confidence interval
Attributable risk
Observational study
Neurology (clinical)
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
dementia
Zdroj: Alzheimers Dement
Ording, A G, Horváth-Puhó, E, Veres, K, Glymour, M M, Rørth, M, Sørensen, H T & Henderson, V W 2020, ' Cancer and risk of Alzheimer's disease : Small association in a nationwide cohort study ', Alzheimer's and Dementia, vol. 16, no. 7, pp. 953-964 . https://doi.org/10.1002/alz.12090
ISSN: 1980-2013
DOI: 10.1002/alz.12090
Popis: Introduction: Small observational studies with short-term follow-up suggest that cancer patients are at reduced risk of Alzheimer's disease (AD) compared to the general population. Methods: A nationwide cohort study using Danish population-based health registries (1980-2013) with cancer patients (n = 949,309) to identify incident diagnoses of AD. We computed absolute reductions in risk attributed to cancer and standardized incidence rate ratios (SIRs) accounting for survival time, comparing the observed to expected number of AD cases. Results: During up to 34 years of follow-up of cancer survivors, the attributable risk reduction was 1.3 per 10,000 person-years, SIR = 0.94 (95% confidence interval 0.92-0.96). SIRs were similar after stratification by sex, age, and cancer stage, and approached that of the general population for those surviving >10 years. Discussion: Inverse associations between cancer and AD were small and diminished over time. Incidence rates in cancer survivors approached those of the general population, suggesting limited association between cancer and AD risk.
Databáze: OpenAIRE
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