Cancer and risk of Alzheimer’s disease: Small association in a nationwide cohort study
Autor: | Mikael Rørth, Erzsébet Horváth-Puhó, Henrik Toft Sørensen, Katalin Veres, Anne Gulbech Ording, Victor W. Henderson, M. Maria Glymour |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Male
Epidemiology Denmark neoplasms Disease 0302 clinical medicine Cancer Survivors Neoplasms 030212 general & internal medicine Registries Child risk Aged 80 and over education.field_of_study Health Policy Incidence Alzheimer's disease Middle Aged Survival Rate Psychiatry and Mental health Child Preschool epidemiology Female Cohort study Adult Risk medicine.medical_specialty Adolescent Population Article 03 medical and health sciences Cellular and Molecular Neuroscience Young Adult Developmental Neuroscience Alzheimer Disease Internal medicine medicine Humans education Aged business.industry Infant Newborn Cancer Infant medicine.disease Confidence interval Attributable risk Observational study Neurology (clinical) Geriatrics and Gerontology business 030217 neurology & neurosurgery dementia |
Zdroj: | Alzheimers Dement Ording, A G, Horváth-Puhó, E, Veres, K, Glymour, M M, Rørth, M, Sørensen, H T & Henderson, V W 2020, ' Cancer and risk of Alzheimer's disease : Small association in a nationwide cohort study ', Alzheimer's and Dementia, vol. 16, no. 7, pp. 953-964 . https://doi.org/10.1002/alz.12090 |
ISSN: | 1980-2013 |
DOI: | 10.1002/alz.12090 |
Popis: | Introduction: Small observational studies with short-term follow-up suggest that cancer patients are at reduced risk of Alzheimer's disease (AD) compared to the general population. Methods: A nationwide cohort study using Danish population-based health registries (1980-2013) with cancer patients (n = 949,309) to identify incident diagnoses of AD. We computed absolute reductions in risk attributed to cancer and standardized incidence rate ratios (SIRs) accounting for survival time, comparing the observed to expected number of AD cases. Results: During up to 34 years of follow-up of cancer survivors, the attributable risk reduction was 1.3 per 10,000 person-years, SIR = 0.94 (95% confidence interval 0.92-0.96). SIRs were similar after stratification by sex, age, and cancer stage, and approached that of the general population for those surviving >10 years. Discussion: Inverse associations between cancer and AD were small and diminished over time. Incidence rates in cancer survivors approached those of the general population, suggesting limited association between cancer and AD risk. |
Databáze: | OpenAIRE |
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