Two antifungal components isolated from Fructus Psoraleae and Folium Eucalypti Globuli by bioassay-guided purification
| Autor: | Simon Q B Han, Ling Cheng, Clara Bik-San Lau, Yin-Lai Wong, Lai-Hong Fu, Chun-Wai Wong, Kwok-Pui Fung, Paul K.S. Chan, Mamie Hui, Ping-Chung Leung, Ching-Po Lau, Kit-Man Lau |
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| Rok vydání: | 2010 |
| Předmět: |
Antifungal Agents
Psoralea corylifolia Trichophyton rubrum Dermatomycosis Phloroglucinol medicine.disease_cause Psoralea chemistry.chemical_compound Phenols Trichophyton Medicine Folium of Descartes Bakuchiol Eucalyptus biology Traditional medicine business.industry Arthrodermataceae General Medicine biology.organism_classification Paecilomyces variotii Plant Leaves Complementary and alternative medicine chemistry Fruit Dermatophyte business Paecilomyces Sesquiterpenes Drugs Chinese Herbal |
| Zdroj: | The American journal of Chinese medicine. 38(5) |
| ISSN: | 1793-6853 |
| Popis: | Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification. |
| Databáze: | OpenAIRE |
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