Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group

Autor:	Tung Le, Raymond J. Bemish, Kyle R. Leeman, Lisa Newell, Stephen T. Colgan, Chiu Charles K, Bryan Li, Richard A. Buzon, William Kissel, Joshua Roth
Rok vydání:	2003
Předmět:	Reaction conditions Aqueous solution Chemistry Organic Chemistry Ether General Medicine Biochemistry High yielding chemistry.chemical_compound Acid sensitive Group (periodic table) Reagent Drug Discovery Organic chemistry Phosphoric acid
Zdroj:	Tetrahedron Letters. 44:8113-8115
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2003.09.040
Popis:	Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction conditions. The reactions are high yielding, and the workup is convenient.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9470133506867cd38053ade09ceb869e https://doi.org/10.1016/j.tetlet.2003.09.040 Zobrazit plný text záznamu Full Text from ScienceDirect