Pulmonary and Mediastinal Glomus Tumors
| Autor: | Frederic B. Askin, Stephen W. Bell, Nobuo Tsuda, Markku Miettinen, Ba Nguyen, David M. Steinberg, Thomas V. Colby, Stephen L. Nishimura, Tomayoshi Hayashi, William D. Travis, Monica Huber, Erich M. Gaertner |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Hemangiosarcoma Mediastinal Neoplasms Pathology and Forensic Medicine Biomarkers Tumor medicine Adjuvant therapy Humans Disseminated disease Aged business.industry fungi Respiratory disease Glomangiosarcoma Mediastinum Middle Aged Glomus Tumor medicine.disease Immunohistochemistry Glomus tumor Malignant Glomus Tumor Radiation therapy Microscopy Electron medicine.anatomical_structure Female Surgery Anatomy business |
| Zdroj: | The American Journal of Surgical Pathology. 24:1105-1114 |
| ISSN: | 0147-5185 |
| DOI: | 10.1097/00000478-200008000-00008 |
| Popis: | Pulmonary and mediastinal glomus tumors are rare lesions, with four previously reported primary pulmonary cases and three mediastinal cases. The authors report one mediastinal glomus tumor, a locally infiltrative type, and four pulmonary glomus tumors, including the first case of primary pulmonary glomangiosarcoma. These tumors show a variety of clinical and pathologic differences from the more common cutaneous variety, including later age at presentation, larger size, and more frequent atypical/malignant features. Mediastinal and pulmonary glomus tumors both have an average patient age at presentation of 45 years. However, compared with their pulmonary counterparts, mediastinal glomus tumors are less common, more often symptomatic, and are larger (average size, 5.4 cm). Additionally, mediastinal glomus tumors more often demonstrate malignant or atypical features. Pulmonary glomus tumors average 3.3 cm in greatest dimension, with the majority measuring less than 2.5 cm. The pulmonary glomangiosarcoma presented was large, measuring 9.5 cm, and showed increased mitotic count (9 mitoses/10 high-power fields), necrosis, cytologic atypia, and was associated with disseminated disease. Regardless of clinical symptoms, histologic features, and even metastases, the vast majority of all benign and malignant glomus tumors are indolent and cured surgically, with adjuvant therapy needed only for occasional patients with more advanced disease. The four patients with glomus tumors reported are currently alive and free of disease as of last follow up. The patient with the glomangiosarcoma developed widespread metastases and died of disease 68 weeks after initial therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|