Electrospun Chitosan/Poly(ethylene oxide)/Lauric Arginate Nanofibrous Film with Enhanced Antimicrobial Activity
| Autor: | Hui Zhang, Fei Que, Hewen Wei, Fengqin Feng, Aiping Zhang, Maierhaba Taxipalati, Lingli Deng |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Staphylococcus aureus
Materials science Polymers Static Electricity Nanofibers Oxide macromolecular substances 02 engineering and technology Arginine 010402 general chemistry 01 natural sciences Polyethylene Glycols Chitosan Contact angle chemistry.chemical_compound Crystallinity Escherichia coli chemistry.chemical_classification Ethylene oxide Food Packaging technology industry and agriculture General Chemistry Polymer 021001 nanoscience & nanotechnology Electrospinning Anti-Bacterial Agents 0104 chemical sciences chemistry Chemical engineering Nanofiber 0210 nano-technology General Agricultural and Biological Sciences Hydrophobic and Hydrophilic Interactions |
| Zdroj: | Journal of Agricultural and Food Chemistry. 66:6219-6226 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/acs.jafc.8b01493 |
| Popis: | In this study, chitosan/poly(ethylene oxide) (PEO)/lauric arginate (LAE) composite nanofibrous films were fabricated via electrospinning. The addition of LAE did not change the physical properties of chitosan/PEO in acetic aqueous solutions, but increased the fluorescent intensity of chitosan by electrostatic interactions, resulting in uniform and bead-free nanofibers with an average diameter of 150 nm. The Fourier transform infrared spectra and thermal analysis indicated that the LAE molecules were homogeneously dispersed within the chitosan/PEO nanofibers. The formation of electrostatic and hydrogen bonding interactions induced by the LAE addition changed the inter- and intramolecular interactions between PEO and chitosan and further affected the mobility of the polymer molecules, leading to the increased crystallinity and decreased melting point. The hydrophilicity of the nanofibrous films was significantly increased by the incorporation of LAE, as indicated by the decreasing water contact angle from 39° to 10°. Meanwhile, the chitosan/PEO/LAE nanofibrous films showed LAE concentration dependent antimicrobial activity against Escherichia coli and Staphylococcus aureus, suggesting enhanced antimicrobial activity. The fluorescent staining experiments demonstrated that the antimicrobial mechanism of the nanofibrous films was cell membrane damage. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|