An 11-Year Surveillance of HIV Type 1 Subtypes in Nagoya, Japan
| Autor: | Naoto Mamiya, Junko Hattori, Motohiro Hamaguchi, Urara Shigemi, Kazuyo Nakamura, Kayoko Shimizu, Saeko Fujisaki, Seiichiro Fujisaki, Shiro Ibe, Yoshiyuki Yokomaku, Tsuguhiro Kaneda, Makoto Utsumi |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Genotype Sequence analysis Molecular Sequence Data Immunology Sequence Homology HIV Infections Biology Genetic analysis Virus law.invention Young Adult Japan law Virology Molecular genetics medicine Animals Humans Phylogeny Aged Recombination Genetic Molecular Epidemiology Molecular epidemiology virus diseases Sequence Analysis DNA Middle Aged Reverse transcriptase Infectious Diseases HIV-1 Recombinant DNA Female |
| Zdroj: | AIDS Research and Human Retroviruses. 25:15-21 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2008.0056 |
| Popis: | To monitor active HIV-1 transmission in Nagoya, Japan, we have been determining the subtypes of HIV-1 infecting therapy-naive individuals who have newly visited the Nagoya Medical Center since 1997. The subtypes were determined by phylogenetic analyses using the base sequences in three regions of the HIV-1 genes including gag p17, pol protease (PR) and reverse transcriptase (RT), and env C2V3. Almost all HIV-1 subtypes from 1997 to 2007 and 93% of all HIV-1 isolates in 2007 were subtype B. HIV-1 subtypes A, C, D, and F have been detected sporadically since 1997, almost all in Africans and South Americans. The first detected circulating recombinant form (CRF ) was CRF01_AE (11-year average annual detection rate, 7.7%). Only two cases of CRF02_AG were detected in 2006. A unique recombinant form (URF ) was first detected in 1998 and the total number of URFs reached 25 by year 2007 (average annual detection rate, 4.7%). Eleven of these 25 were detected from 2000 to 2005 and had subtypes AE/B/AE as determined by base sequencing of the gag p17, pol PR and RT, and env C2V3 genes (average annual detection rate, 3.7%). Unique subtype B has been detected in six cases since 2006. All 17 of these patients were Japanese. Other recombinant HIV-1s have been detected intermittently in eight cases since 1998. During the 11-year surveillance, most HIV-1s in Nagoya, Japan were of subtype B. We expect that subtype B HIV-1 will continue to predominate for the next several years. Active recombination between subtype B and CRF01_AE HIV-1 and its transmission were also shown. |
| Databáze: | OpenAIRE |
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