| Autor: |
Beatriz Calloni, Masiero, Bruno, Calsa, Camila Andreia, Oliveira, Thiago Antônio, Moretti de Andrade, Marcelo Augusto Marretto, Esquisatto, Rosana, Catisti |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Annals of Anatomy - Anatomischer Anzeiger. 241:151889 |
| ISSN: |
0940-9602 |
| DOI: |
10.1016/j.aanat.2022.151889 |
| Popis: |
Cardiovascular diseases affect a large part of the population during adulthood. Several epidemiological and experimental studies have demonstrated an association between maternal protein restriction and a marked risk of developing heart disease during early intrauterine and postnatal life. Maternal nutritional conditions act by modulating the microenvironment, thus favoring adaptive processes of the fetal organism for development to occur. However, the physiological profile is established in this period and its effects can be observed in the long term. In the present study, the cardiac muscles of 15-day-old offspring of Wistar rats subjected to maternal protein restriction during pregnancy and/or lactation were evaluated to identify possible cardiac changes relevant for heart disease in adulthood. The offspring of restricted female rats during pregnancy had a lower birth weight. Male offspring subjected to restriction during pregnancy and lactation showed an increase in the concentration of H |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect