Correlative BOLD MR imaging of stages of synovitis in a rabbit model of antigen-induced arthritis
| Autor: | Rahim Moineddin, Maria Mendes, Adrian P. Crawley, Andrea S. Doria, Anguo Zhong, Roland Jong, Harpal K. Gahunia, Vivian Tassos, Robert B. Salter, Kenneth P.H. Pritzker, Tammy Rayner |
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| Rok vydání: | 2011 |
| Předmět: |
musculoskeletal diseases
Male medicine.medical_specialty medicine.medical_treatment Inflammatory arthritis Statistics as Topic Arthritis Sensitivity and Specificity Synovitis medicine Animals Humans Radiology Nuclear Medicine and imaging Antigens Saline Serum Albumin Neuroradiology Hyperoxia business.industry Ultrasound Reproducibility of Results medicine.disease Magnetic Resonance Imaging Disease Models Animal Pediatrics Perinatology and Child Health Rabbit model Radiology Rabbits medicine.symptom business |
| Zdroj: | Pediatric radiology. 42(1) |
| ISSN: | 1432-1998 |
| Popis: | Because of the ability of blood-oxygen-level-dependent (BOLD) MRI to assess blood oxygenation changes within the microvasculature, this technique holds potential for evaluating early perisynovial changes in inflammatory arthritis. To evaluate the feasibility of BOLD MRI to detect interval perisynovial changes in knees of rabbits with inflammatory arthritis. Rabbit knees were injected with albumin (n = 9) or saline (n = 6) intra-articularly, or were not injected (control knees, n = 9). Except for two rabbits (albumin-injected, n = 2 knees; saline-injected, n = 2 knees) that unexpectedly died on days 7 and 21 of the experiment, respectively, all other animals were scanned with BOLD MRI on days 0, 1, 7, 14, 21 and 28 after induction of arthritis. T2*-weighted gradient-echo MRI was performed during alternate 30 s of normoxia/hyperoxia. BOLD MRI measurements were compared with clinical, laboratory and histological markers. Percentage of activated voxels was significantly greater in albumin-injected knees than in contralateral saline-injected knees (P = 0.04). For albumin-injected knees (P |
| Databáze: | OpenAIRE |
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