Early proctoscopy is a surrogate endpoint of late rectal toxicity in prostate cancer treated with radiotherapy
| Autor: | Mariangela Massaccesi, Daniele Cuscunà, Gian Carlo Mattiucci, Giovanna Mantini, Numa Cellini, Vincenzo Valentini, Cinzia Digesù, Gabriella Macchia, Giuseppe Antonio Pirozzi, Francesco Deodato, Edy Ippolito, Marcello Ingrosso, Alessio G. Morganti, Savino Cilla, Alessandra Di Lallo, Fabio Pacelli |
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| Přispěvatelé: | Ippolito E, Massaccesi M, Digesù C, Deodato F, Macchia G, Pirozzi GA, Cilla S, Cuscunà D, Di Lallo A, Mattiucci GC, Mantini G, Pacelli F, Valentini V, Cellini N, Ingrosso M, Morganti AG |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Rectum Adenocarcinoma Gastroenterology Proctoscopy Vienna Rectoscopy Score Rectal bleeding Prostate cancer Intestinal mucosa Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Telangiectasis Intestinal Mucosa Radiation Injuries Radiation medicine.diagnostic_test Radiotherapy Surrogate endpoint business.industry Prostatic Neoplasms Radiotherapy Dosage medicine.disease Surgery Radiation therapy medicine.anatomical_structure Rectal Diseases Oncology Toxicity business Gastrointestinal Hemorrhage Late toxicity |
| Popis: | Purpose To predict the grade and incidence of late clinical rectal toxicity through short-term (1 year) mucosal alterations. Methods and Materials Patients with prostate adenocarcinoma treated with curative or adjuvant radiotherapy underwent proctoscopy a year after the course of radiotherapy. Mucosal changes were classified by the Vienna Rectoscopy Score (VRS). Late toxicity data were analyzed according to the Kaplan-Meier method. Comparison between prognosis groups was performed by log-rank analysis. Results After a median follow-up time of 45 months (range, 18–99), the 3-year incidence of grade ≥2 rectal late toxicity according to the criteria of the European Organization for Research and Treatment of Cancer and the Radiation Therapy Oncology Group was 24%, with all patients (24/24; 100%) experiencing rectal bleeding. The occurrence of grade ≥2 clinical rectal late toxicity was higher in patients with grade ≥2 (32% vs. 15 %, p = 0.02) or grade ≥3 VRS telangiectasia (47% vs. 17%, p ≤ 0.01) and an overall VRS score of ≥2 (31% vs. 16 %, p = 0.04) or ≥3 (48% vs. 17%, p = 0.01) at the 1-year proctoscopy. Conclusions Early proctoscopy (1 year) predicts late rectal bleeding and therefore can be used as a surrogate endpoint for late rectal toxicity in studies aimed at reducing this frequent complication. |
| Databáze: | OpenAIRE |
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