Non-invasive diagnosis of early pulmonary disease in PECAM-deficient mice using infrared pulse oximetry
| Autor: | John Gilchrist, Alan R. Schenkel, William A. Muller, Mercedes Gonzalez-Juarerro, David M. Higgins, Marta Lishnevsky, Ian M. Orme, Merideth A. Early |
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| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Infrared Rays Clinical Biochemistry Article Pathology and Forensic Medicine Pulmonary function testing Mice Fibrosis medicine Animals Oximetry Diffuse alveolar damage Molecular Biology Oxygen saturation (medicine) Lung medicine.diagnostic_test business.industry Respiratory disease Interstitial lung disease medicine.disease Immunohistochemistry Mice Mutant Strains Oxygen Platelet Endothelial Cell Adhesion Molecule-1 Pulse oximetry Disease Models Animal medicine.anatomical_structure Early Diagnosis business Lung Diseases Interstitial |
| Zdroj: | Experimental and molecular pathology. 87(2) |
| ISSN: | 1096-0945 |
| Popis: | Pulse oximetry is a common tool for detecting reduced pulmonary function in human interstitial lung diseases. It has not previously been used in a mouse model of interstitial lung disease. Further, platelet endothelial cell adhesion molecule deficient mice rarely show symptoms until disease is advanced. Using blood oxygen saturation, different stages of disease could be identified in a non-invasive manner. These stages could be correlated to pathology. Collagen deposition, using Picrosirius Red, did correlate with blood oxygen saturation. These studies are the first to show the use of an infrared pulse oximetry system to analyze the progression of a fibrotic interstitial lung disease in a mouse model of the human diseases. Further, these studies show that an early alveolar damage/enlargement event precedes the fibrosis in this mouse model, a stage that represents the best targets for disease analysis and prevention. This stage does not have extensive collagen deposition. Most importantly, targeting this earliest stage of disease for therapeutic intervention may lead to novel treatment for human disease. |
| Databáze: | OpenAIRE |
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