Chondroitin sulfate synthase 1 expression is associated with malignant potential of soft tissue sarcomas with myxoid substance

Autor: Ken'ichi Isobe, Jun Nakayama, Hiroyuki Kato, Mana Fukushima, Takashige Momose, Yasuo Yoshimura, Satoru Harumiya, Munehisa Kito
Rok vydání: 2015
Předmět:
0301 basic medicine
Adult
Male
Pathology
medicine.medical_specialty
Time Factors
Adolescent
Fibrosarcoma
Malignant peripheral nerve sheath tumor
Soft Tissue Neoplasms
Fibroma
Kaplan-Meier Estimate
Biology
N-Acetylglucosaminyltransferases
Nerve Sheath Neoplasms
Pathology and Forensic Medicine
03 medical and health sciences
chemistry.chemical_compound
Young Adult
Chondroitin sulfate synthase 1
medicine
Biomarkers
Tumor
Humans
Chondroitin sulfate
Glucuronosyltransferase
Child
Aged
Neoplasm Staging
Proportional Hazards Models
Aged
80 and over
Myxoid liposarcoma
Soft tissue sarcoma
Myxofibrosarcoma
Middle Aged
medicine.disease
Immunohistochemistry
Multifunctional Enzymes
Liposarcoma
Myxoid
030104 developmental biology
Treatment Outcome
chemistry
N-Acetylgalactosaminyltransferases
Female
Sarcoma
Neoplasm Grading
Zdroj: Human pathology. 50
ISSN: 1532-8392
Popis: The glycosyltransferases chondroitin sulfate synthase 1 (CHSY1) and exostoses-like 3 (EXTL3) specifically function in biosynthesis of the glycans chondroitin sulfate and heparan sulfate, respectively. Although these glycans play important roles in pathogenesis of various tumors, their significance in soft tissue sarcoma remains unknown. Here, we asked whether CHSY1 or EXTL3 expression correlates with malignant potential of soft tissue sarcomas with myxoid substance. To do so, we examined 40 samples representing specific types, including 12 cases of myxoid liposarcoma, 14 of myxofibrosarcoma, 12 of malignant peripheral nerve sheath tumor, and 2 of low-grade fibromyxoid sarcoma. We performed immunohistochemistry with anti-CHSY1 and anti-EXTL3 antibodies and compared enzyme expression levels with tumor histologic grade as assessed by the Federation Nationale des Centres de Lutte Contre le Cancer classification and with patient 5-year survival rate. CHSY1 and EXTL3 were expressed in 72.5% and 32.5% of all tumors, respectively. Notably, CHSY1 was strongly expressed in myxofibrosarcoma and malignant peripheral nerve sheath tumor compared with other tumors and significantly associated with higher- rather than lower-grade tumors (P < .01). High expression of CHSY1 was also significantly associated with poorer patient outcomes (P = .031) and higher stages assessed by American Joint Committee on Cancer staging system (P = .004). By contrast, EXTL3 expression was not correlated with histologic grade or patient prognosis. We conclude that CHSY1 expression is closely associated with malignant potential of soft tissue sarcomas with myxoid substance.
Databáze: OpenAIRE
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