2'-Hydroxymatteucinol, a New C-Methyl Flavanone Derivative from Matteccia orientalis; Potent Hypoglycemic Activity in Streptozotocin (STZ)-Induced Diabetic Rat
| Autor: | Mineo Shimizu, Shigetoshi Kadota, Tsuneo Namba, Hong-Xi Xu, Purusotam Basnet |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Stereochemistry Flavonoid Blood sugar Pharmacology Pharmacognosy Flavones Streptozocin Diabetes Mellitus Experimental Rats Sprague-Dawley Mice chemistry.chemical_compound Diabetes mellitus Drug Discovery medicine Animals Hypoglycemic Agents Flavonoids chemistry.chemical_classification Biological activity General Chemistry General Medicine Plants medicine.disease Streptozotocin Rats chemistry Flavanone medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 41:1790-1795 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | The CHCl3 extract of Matteccia orientalis showed very strong hypoglycemic activity in streptozotocin (STZ)-induced diabetic rats. A new C-methyl flavanone derivative, 2'-hydroxymatteucinol (3) was isolated from the hypoglycemic activity bearing fraction, along with two known compounds, demethoxymatteucinol (1) and matteucinol (2). The structures of these isolated compounds were elucidated by spectroscopic methods. One of the compounds isolated from CHCl3 extract, 2'-hydroxymatteucinol (3), showed dose-dependent hypoglycemic activity, and a blood sugar lowering effect was observed even at the dose of 10 mg/kg (p.o.) in STZ-induced diabetic rats. |
| Databáze: | OpenAIRE |
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