The N-type and L-type calcium channel blocker cilnidipine suppresses renal injury in Dahl rats fed a high-salt diet
| Autor: | Hajime Koganei, Hirotaka Wagatsuma, Tetsuya Ogawa, Shizuka Aritomi, Akira Mitsui, Tomoyuki Konda, Kosaku Nitta |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Angiotensin receptor Dihydropyridines Time Factors Calcium Channels L-Type medicine.drug_class Renal function Tetrazoles Blood Pressure Calcium channel blocker Pharmacology Kidney Rats Sprague-Dawley Calcium Channels N-Type Glomerulonephritis Internal medicine medicine Albuminuria Animals L-type calcium channel Amlodipine Sodium Chloride Dietary Antihypertensive Agents Rats Inbred Dahl business.industry Valine Organ Size Cilnidipine Calcium Channel Blockers Angiotensin II Rats Disease Models Animal Endocrinology Valsartan Hypertension Drug Therapy Combination Kidney Diseases Cardiology and Cardiovascular Medicine business Angiotensin II Type 1 Receptor Blockers Biomarkers medicine.drug |
| Zdroj: | Heart and vessels. 25(6) |
| ISSN: | 1615-2573 |
| Popis: | The aims of the present study were to compare the effects of cilnidipine [L-type/N-type calcium channel blocker (CCB)] and amlodipine (L-type CCB) alone or in combination with the angiotensin II receptor blocker (ARB), valsartan, on blood pressure (BP), kidney function in Dahl salt-sensitive (DS) rats. DS rats fed a high-salt diet were divided into six groups; control (n = 13), two CCB (cilnidipine or amlodipine) groups at 1 mg/kg/day (n = 10), ARB (valsartan) at 10 mg/kg/day (n = 12), cilnidipine + valsartan (CV, n = 12), and amlodipine + valsartan (AV, n = 12). BPs were lower in the combination therapy groups than in those given either drug alone, but only CV inhibited the increase in urinary albumin excretion (UAE) and lowered the glomerular sclerosis score. In addition, AV elevated plasma renin activity and the angiotensin II concentration, and thus failed to inhibit increases in UAE and to lower glomerular sclerosis score. In conclusion, combination therapy with CCB and ARB decreases BP more effectively than either drug alone. When used in combination with valsartan, cilnidipine is more effective than amlodipine for preventing kidney injury. |
| Databáze: | OpenAIRE |
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