Multiplex Immunoassay Techniques for On-Site Detection of Security Sensitive Toxins
| Autor: | Thomas Elßner, Christopher Pöhlmann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Health
Toxicology and Mutagenesis multiplex immunoassay platforms lcsh:Medicine 02 engineering and technology Computational biology Review Biology Toxicology 01 natural sciences Antibodies chemistry.chemical_compound medicine Multiplex Toxins Biological Saxitoxin Immunoassay Heterogeneous group medicine.diagnostic_test optical biosensor 010401 analytical chemistry lcsh:R proteotoxins 021001 nanoscience & nanotechnology low molecular weight toxins Bioterrorism 0104 chemical sciences Highly sensitive electrochemical biosensor Ricin chemistry Natural food on-site detection Abrin 0210 nano-technology security sensitive toxins |
| Zdroj: | Toxins Toxins, Vol 12, Iss 727, p 727 (2020) |
| ISSN: | 2072-6651 |
| Popis: | Biological toxins are a heterogeneous group of high molecular as well as low molecular weight toxins produced by living organisms. Due to their physical and logistical properties, biological toxins are very attractive to terrorists for use in acts of bioterrorism. Therefore, among the group of biological toxins, several are categorized as security relevant, e.g., botulinum neurotoxins, staphylococcal enterotoxins, abrin, ricin or saxitoxin. Additionally, several security sensitive toxins also play a major role in natural food poisoning outbreaks. For a prompt response to a potential bioterrorist attack using biological toxins, first responders need reliable, easy-to-use and highly sensitive methodologies for on-site detection of the causative agent. Therefore, the aim of this review is to present on-site immunoassay platforms for multiplex detection of biological toxins. Furthermore, we introduce several commercially available detection technologies specialized for mobile or on-site identification of security sensitive toxins. |
| Databáze: | OpenAIRE |
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