Efficacy of multi-strain probiotic along with dietary and lifestyle modifications on polycystic ovary syndrome: a randomised, double-blind placebo-controlled study

Autor:	Ishwarpreet Kaur, Vanita Suri, Naresh Sachdeva, Satya Vati Rana, Bikas Medhi, Nancy Sahni, Jayesh Ahire, Amarjeet Singh
Rok vydání:	2022
Předmět:	Adult Blood Glucose Lipopolysaccharides Nutrition and Dietetics Adolescent Probiotics Medicine (miscellaneous) Dehydroepiandrosterone Luteinizing Hormone Body Mass Index Diet Young Adult Weight Loss Quality of Life Humans Insulin Female Testosterone Follicle Stimulating Hormone Insulin Resistance Life Style Polycystic Ovary Syndrome
Zdroj:	European Journal of Nutrition. 61:4145-4154
ISSN:	1436-6215 1436-6207
Popis:	Effect of multi-strain probiotic along with dietary and lifestyle modifications in the management of polycystic ovary syndrome (PCOS) has rarely been reported. We thus aimed to investigate the effect of multi-strain probiotic (Lactobacillus acidophilus UBLA-34, L. rhamnosus UBLR-58, L. reuteri UBLRu-87 (each of 2 billion colony forming units (CFU)); L. plantarum UBLP-40, L. casei UBLC-42, L. fermentum UBLF-31, Bifidobacterium bifidum UBBB-55 (each of 1 billion CFU) and fructo-oligosaccharides (100 mg)) and dietary and lifestyle modifications on restoration of menstrual regularity, weight reduction, metabolic and hormonal profile in women with PCOS.A 104 participants (age 18-40 years) were randomly allocated to receive probiotic or placebo capsules for 6 months. Baseline and end line assessment were performed for menstrual cycle regularity, ultrasonography scan for ovaries, total testosterone, dehydroepiandrosterone (DHEAS), insulin, luteinizing hormone/follicle stimulating hormone (LH/FSH) ratio, fasting blood sugar (FBS), homeostatic model assessment-insulin resistance (HOMA-IR), weight reduction, waist-/hip circumference (WC, HC), waist to hip ratio (WHR), and body mass index (BMI). Plasma lipopolysaccharide and effect of intervention on quality of life was investigated. Diet and exercise were controlled during the trial.Probiotic supplement along with dietary and lifestyle modifications significantly regularised menstrual cycle (p 0.023), improved levels of total testosterone (p 0.043), WC (p 0.030), WHR (p 0.027) and menstrual domain of quality of life (p 0.034) as compared to placebo. No adverse events related to study were reported.Multi-strain probiotic along with dietary and lifestyle modifications were effective in the management of PCOS.CTRI: CTRI/2016/07/007086, dated 13 July 2016.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9388f1f0391404f4fd392697ffc309a4 https://doi.org/10.1007/s00394-022-02959-z Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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