Utility of 18F-FDG-PET for detecting acute lymphoblastic leukemia: a case series of pediatric acute lymphoblastic leukemia without hematological symptoms
| Autor: | Raita Araki, Taizo Wada, Rie Kuroda, Mika Takenaka, Shintaro Mase, Yuta Sakai, Akihiro Yachie, Ryosei Nishimura, Kazuhiro Noguchi, Yasuhiro Ikawa, Hideaki Maeba, Toshihiro Fujiki, Masaki Fukuda |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Anemia Gastroenterology Bone and Bones Fluorodeoxyglucose F18 Internal medicine medicine Humans Child Acute leukemia Hematology business.industry Osteomyelitis Chronic recurrent multifocal osteomyelitis Bone fracture Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia medicine.anatomical_structure Child Preschool Positron-Emission Tomography Female Bone marrow Radiopharmaceuticals business |
| Zdroj: | International journal of hematology. 115(2) |
| ISSN: | 1865-3774 |
| Popis: | Acute leukemia is typically diagnosed from presenting features related to hematological symptoms, but certain patients present with prominent musculoskeletal pain without signs of hematological abnormality. We reviewed the medical records of 58 children diagnosed with acute lymphoblastic leukemia (ALL) at our hospital to evaluate initial features. Forty six of these patients had hematological symptoms, anemia, or hemorrhage (Group H), while 12 patients had prominent musculoskeletal pain without hematological symptoms (Group P). Diagnosis of leukemia took significantly more time for those 12 patients (Group H, 17.1 days; Group P, 48.5 days). In three of the 12 patients in Group P, localized abnormal imaging findings and unremarkable blood test results led to initial diagnoses of chronic recurrent multifocal osteomyelitis, bone fracture, and septic osteomyelitis. However, 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) revealed multiple intense bone foci or systemic bone marrow uptake, leading to the diagnosis of ALL. A review of 18F-FDG-PET results from 23 patients with ALL who underwent a PET scan (Group H, n = 15; Group P, n = 8) showed multiple bone foci or systemic bone marrow uptake in all cases. In conclusion, lack of hematological symptoms in ALL patients can delay diagnosis, and 18F-FDG-PET is useful for diagnosing leukemia in such cases. |
| Databáze: | OpenAIRE |
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