Prenatal diagnosis of diffuse mesangial glomerulosclerosis by ultrasonography: a longitudinal study of a case in an affected family
| Autor: | J.W. Dudenhausen, I. Neumann, C. Hofstaetter, T. Lennert |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Embryology Longitudinal study Pathology medicine.medical_specialty Nephrotic Syndrome Consanguineous family Prenatal diagnosis Ultrasonography Prenatal Consanguinity Fatal Outcome Pregnancy Medicine Humans Radiology Nuclear Medicine and imaging Renal Insufficiency Fetus business.industry Obstetrics Infant Newborn Obstetrics and Gynecology Glomerulosclerosis Glomerulonephritis General Medicine medicine.disease Infant mortality Arabs Pedigree Pediatrics Perinatology and Child Health Female Ultrasonography business Follow-Up Studies |
| Zdroj: | Fetal diagnosis and therapy. 11(2) |
| ISSN: | 1015-3837 |
| Popis: | The 4th child of an Arabian consanguineous family with 2 previous infant deaths due to diffuse mesangial glomerulosclerosis (at the ages of 1 and 44 days) and 1 healthy 3-year old child was followed up by ultrasonography from the 9th until the 35th week of gestation. Ultrasound showed enlarged hyperechogenic kidneys from the 14th week onwards, and the amniotic fluid level was increased to the upper normal limit. An amniocentesis at 14+ weeks of gestation showed a normal male karyotype and normal alpha-fetoprotein levels in amniotic fluid and maternal serum. Albumin and alpha 1-microglobulin levels in the amniotic fluid were within the normal range and not useful for diagnostic purposes. The child was born at the 36th week of gestation and died of renal failure 21 days later. A postmortem renal biopsy specimen revealed diffuse mesangial glomerulosclerosis. |
| Databáze: | OpenAIRE |
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