Early and Solid Protection Afforded by the Thiverval Vaccine Provides Novel Vaccination Alternatives Against Classical Swine Fever Virus
| Autor: | Lamothe-Reyes, Yaneysis, Bohórquez, José Alejandro, Wang, Miaomiao, Alberch, Mònica, Pérez-Simó, Marta, Ganges, Llilianne, Rosell, Rosa |
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| Přispěvatelé: | Producció Animal, Sanitat Animal |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
040301 veterinary sciences Immunology virological protection Virulence Virus Article immune response Thiverval strain 0403 veterinary science 03 medical and health sciences Immune system vaccine Drug Discovery Post vaccination Medicine Pharmacology (medical) Pharmacology biology business.industry Transmission (medicine) 04 agricultural and veterinary sciences biology.organism_classification vaccination Virology Vaccination clinical protection 030104 developmental biology Infectious Diseases Viral replication Classical swine fever challenge CSFV business |
| Zdroj: | Vaccines IRTA Pubpro. Open Digital Archive Institut de Recerca i Tecnologia Agroalimentàries (IRTA) Volume 9 Issue 5 Vaccines, Vol 9, Iss 464, p 464 (2021) |
| Popis: | Classical swine fever virus (CSFV) remains a challenge for the porcine industry. Inefficient vaccination programs in some endemic areas may have contributed to the emergence of low and moderate virulence CSFV variants. This work aimed to expand and update the information about the safety and efficacy of the CSFV Thiverval-strain vaccine. Two groups of pigs were vaccinated, and a contact and control groups were also included. Animals were challenged with a highly virulent CSFV strain at 21- or 5-days post vaccination (dpv). The vaccine induced rapid and strong IFN-α response, mainly in the 5-day immunized group, and no vaccine virus transmission was detected. Vaccinated pigs showed humoral response against CSFV E2 and Erns glycoproteins, with neutralising activity, starting at 14 days post vaccination (dpv). Strong clinical protection was afforded in all the vaccinated pigs as early as 5 dpv. The vaccine controlled viral replication after challenge, showing efficient virological protection in the 21-day immunized pigs despite being housed with animals excreting high CSFV titres. These results demonstrate the high efficacy of the Thiverval strain against CSFV replication. Its early protection capacity makes it a useful alternative for emergency vaccination and a consistent tool for CSFV control worldwide. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
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