Decreased collagen concentration in rat uterine implantation sites compared with non-implantation tissue at days 6-11 of pregnancy
| Autor: | DE Clark, P. R. Hurst, DB Myers |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
Uterus Implantation Site Reproductive technology Biology Capillary Permeability Endocrinology Pregnancy Internal medicine Genetics medicine Decidua Animals Embryo Implantation Molecular Biology Fertilisation Myometrium Decidualization Proteins Rats Inbred Strains Organ Size medicine.disease Rats medicine.anatomical_structure Reproductive Medicine Pregnancy Animal Animal Science and Zoology Female Collagen Developmental Biology Biotechnology |
| Zdroj: | Reproduction, fertility, and development. 2(6) |
| ISSN: | 1031-3613 |
| Popis: | Collagen concentrations at implantation sites in the rat uterus were found to be significantly decreased compared with concentrations in adjacent non-involved uterine tissue in early pregnancy (75% by Day 11). The decrease in collagen was most marked in primary decidua and was also observed to a lesser extent (20%) in myometrium at the implantation site. There was a decrease of 20% in the concentration of total proteins at Day 7 (as measured by the ninhydrin method) and a slight increase in water content (2%) at Days 6 and 7. The differences in total protein and water content were transient, but the difference in collagen was maintained throughout early pregnancy. The localized changes in collagen content observed in this study, along with previously reported morphological changes in fibrillar and basement-membrane collagens in the uterus, give support to a theory of remodelling in early pregnancy involving simultaneous synthesis and degradation of extracellular proteins during decidualization. |
| Databáze: | OpenAIRE |
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