CYP2C19 polymorphism has no influence on rabeprazole-based hybrid therapy forHelicobacter pylorieradication
| Autor: | Kuan-Yang Chen, Tsung-Jung Lin, Chih-Lin Lin, Chung-Kwe Wang, Deng-Chyang Wu, Hsi-Chang Lee |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Rabeprazole macromolecular substances CYP2C19 Gastroenterology 03 medical and health sciences 0302 clinical medicine Cytochrome P450 2C19 Internal medicine Medicine Helicobacter pylori biology business.industry Hybrid therapy General Medicine Basic Study bacterial infections and mycoses biology.organism_classification Interleukin-1β Interleukin 1β 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business medicine.drug |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| DOI: | 10.12998/wjcc.v6.i12.514 |
| Popis: | AIM To evaluate the impact of cytochrome P450 2C19 (CYP2C19) and interleukin-1β (IL-1β) polymorphisms on the efficacy of Helicobacter pylori (H. pylori) eradication by using rabeprazole-based hybrid therapy. METHODS A total of 88 H. pylori-infected patients were recruited to receive 14-d of hybrid therapy from March 2013 to May 2014. Three patients were excluded from analysis because of incomplete compliance. Either a follow-up endoscopy or 13C-urea test was performed to determine the results of H. pylori eradication therapy. The genotypes of CYP2C19 and IL-1β were analyzed to investigate the impact on treatment effect. RESULTS The total eradication rate of H. pylori was 92.94% (79/85). According to the CYP2C19 genotypes, the rates of H. pylori eradication were 89.19% in extensive metabolizers (EM) and 95.83% in non-EM. The H. pylori eradication rates regarding the IL-1β genotypes were 92.59% in the normal acid secretion group and 93.10% in the low acid secretion group. After multivariable logistic regression analysis, both the genotypes of CYP2C19 and IL-1β had no significant influences on the eradication rates of H. pylori. CONCLUSION The CYP2C19 and IL-1β polymorphisms are not significantly independent factors of H. pylori eradication using rabeprazole-based hybrid therapy. |
| Databáze: | OpenAIRE |
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