IMPROVED RETENTION OF STROMA-FREE HEMOGLOBIN SOLUTION BY CHEMICAL MODIFICATION
| Autor: | Gerald Peskin, Mark Schooley, Greenburg Ag |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Stroma-free hemoglobin
Chromatography business.industry Resuscitation Plasma Substitutes Chemical modification Critical Care and Intensive Care Medicine Oxygen Solutions Hemoglobins Dogs High oxygen Oxyhemoglobins Pyridoxal Phosphate Animals Medicine Surgery Rabbits Hemoglobin business Retention time |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 17:501-504 |
| ISSN: | 0022-5282 |
| Popis: | The major problems requiring solution before full-scale evaluation of stroma-free hemoglobin solution (SFHS) in a clinical environment are its high oxygen affinity and relatively short intravascular retention time. Through postmanufacture chemical modification of SFHS we have been able to improve both properties as determined in in vitro and in vivo studies. Permatization of SFHS with pyridoxal 5'-phosphate (PLP) does not affect oxygen-carrying capacity and improves the P50 and intravascular retention. This chemically modified hemoglobin is worthy of further evaluation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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