Is vitamin D hypothesis for schizophrenia valid? Independent segregation of psychosis in a family with vitamin-D-dependent rickets type IIA
| Autor: | Hamza Okur, Aylin Uluşahin, A. Gögüs, Turgay Coşkun, Timur Tuncali, Suzan Özer, A. Nurten Akarsu, Semra Ulusoy |
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| Rok vydání: | 2004 |
| Předmět: |
Vitamin
Adult Male Candidate gene medicine.medical_specialty Psychosis Adolescent Genetic Linkage Rickets Biology Calcitriol receptor vitamin D deficiency chemistry.chemical_compound Internal medicine medicine Vitamin D and neurology Odds Ratio Humans Genetic Predisposition to Disease Bipolar disorder Biological Psychiatry Aged Pharmacology Aged 80 and over Family Health Chromosomes Human Pair 12 Alopecia Middle Aged medicine.disease Vitamin D Deficiency Pedigree Endocrinology Phenotype chemistry Psychotic Disorders Schizophrenia Receptors Calcitriol Female |
| Zdroj: | Progress in neuro-psychopharmacologybiological psychiatry. 28(2) |
| ISSN: | 0278-5846 |
| Popis: | The vitamin D hypothesis of schizophrenia is a recent concept bringing together old observations on environmental risk factors and new findings on the neurodevelopmental effects of vitamin D. Candidate genes related to the vitamin D endocrine system have not yet been fully explored for this purpose. The coexistence of vitamin-D-dependent-rickets type II with alopecia (VDDR IIA) and different forms of psychosis in the same inbred family has provided us with an opportunity to investigate the presumed relationship between vitamin D deficiency and psychosis. Psychiatric examination and molecular genetic studies were performed in this family overloaded with psychotic disorders and VDDR IIA. Forty members were evaluated in order to describe their phenotypic features. The family was tested for a linkage to the chromosome 12q12-q14 region where the vitamin D receptor (VDR) gene is located. Psychosis was the common phenotype in the 18 psychiatrically affected members. Pedigree analysis did not show a cosegregation of psychosis and rickets. Lod scores were not significant to prove a linkage between psychosis and VDR locus. The authors concluded that (1) the neurodevelopmental consequences of vitamin D deficiency do not play a causative role in psychotic disorders, (2) these two syndromes are inherited independently, and (3) vitamin D deficiency does not act as a risk factor in subjects susceptible to psychosis. |
| Databáze: | OpenAIRE |
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