Vitamin D3 compounds regulate human immunodeficiency virus type 1 replication in U937 monoblastoid cells and in monocyte-derived macrophages
| Autor: | C D Pauza, L J Deftos, Richard S. Kornbluth, P Emau, Douglas D. Richman |
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| Rok vydání: | 1993 |
| Předmět: |
Cellular differentiation
Immunology Biology Virus Replication Monocytes Virus Structure-Activity Relationship Calcitriol HIV Seropositivity Tumor Cells Cultured medicine Humans Immunology and Allergy Macrophage Cells Cultured Calcifediol Cholecalciferol Innate immune system U937 cell Macrophages Monocyte Cell Biology Virology Kinetics medicine.anatomical_structure Viral replication Cell culture HIV-1 |
| Zdroj: | Journal of Leukocyte Biology. 53:157-164 |
| ISSN: | 1938-3673 0741-5400 |
| DOI: | 10.1002/jlb.53.2.157 |
| Popis: | We studied the effects of vitamin D3 compounds on the replication of human immunodeficiency virus type 1 (HIV-1) in the monoblastoid cell line U937 and in primary monocyte-derived macrophage cultures to understand how modulators of monocyte/macrophage effector function might affect the pathogenesis of HIV-1 infection. U937 cell cultures exposed to 1,α25-dihydro- xyvitamin D3 prior to HIV-1 infection showed enhanced virus replication that was apparently due to increased cellular resistance to viral cytopathic effects; a marked inhibition of virus replication was noted in cells exposed to 1,α25-dihydroxyvitamin D3 subsequent to infection. Exposure of blood-derived monocyte/macrophages to vitamin D3 compounds prior to infection also affected virus growth; in most cases, substantial inhibition of HIV- 1 replication was noted in vitamin D3-treated macrophage cultures. Our results demonstrate that vitamin D3 compounds with recognized abilities to induce cellular differentiation can modulate HIV-1 infection of human macrophages. J. Leukoc. Biol. 53: 157–164; 1993. |
| Databáze: | OpenAIRE |
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