Evolution and Expression of S100A7 Gene in Vertebrates
| Autor: | Yang Ding, Husile Gong, Jianghong Wu, Wenguang Zhang, Yunxia Qi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Transcription Genetic Ultraviolet Rays Nocturnal bottleneck Gene Expression Biology medicine.disease_cause Biochemistry S100 Calcium Binding Protein A7 Evolution Molecular 03 medical and health sciences 0302 clinical medicine Species Specificity Transcription (biology) Phylogenetics biology.animal Gene expression Genetics medicine Cashmere goat Animals Selection Genetic Molecular Biology Gene Ecology Evolution Behavior and Systematics Phylogeny Skin Likelihood Functions Vertebrate General Medicine DNA Cell biology 030104 developmental biology 030220 oncology & carcinogenesis Vertebrates Seasons Sequence Alignment Ultraviolet |
| Zdroj: | Biochemical genetics. 57(3) |
| ISSN: | 1573-4927 |
| Popis: | The skin is the primary barrier between the internal organs of an organism and the environment, and it provides protection from ultraviolet (UV) radiation. According to the nocturnal bottleneck hypothesis, ungulates might have traversed to the grasslands and were exposed to UV radiation subsequent to the reduction in predation pressure. UV light exposure might have increased the S100A7 expression. In order to test whether the UV radiation is associated with the selection pressure on S100A7, we acquired the complete S100A7 DNA sequences from each of 42 vertebrate species. The results suggested that the evidence of diversifying selection in S100A7 occurred at the end of Mesozoic era, and the site of positive selection was observed in the branch of Artiodactyla (even-toed ungulates). In addition, we found that the transcription level of S100A7 in cashmere goat skin correlates with UV radiation. Our results indicated that S100A7 plays a role in the signaling between the skin genes and UV radiation during evolution. |
| Databáze: | OpenAIRE |
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