Salmonid Alphavirus Subtype 3 Induces Prolonged Local B Cell Responses in Atlantic Salmon (Salmo salar) After Intraperitoneal Infection
| Autor: | Ma Michelle Demogina Penaranda, Ingvill Jensen, Hanna L. Thim, Guro Strandskog, Shiferaw Jenberie, Jorunn B. Jørgensen, Morten Bay Styrvold |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine Atlantic salmon animal diseases Immunology Spleen Alphavirus Salmonid alphavirus 03 medical and health sciences Peritoneal cavity 0302 clinical medicine Immune system medicine Immunology and Allergy Salmo Neutralizing antibody B cell VDP::Landbruks- og Fiskerifag: 900::Fiskerifag: 920 B cells VDP::Agriculture and fishery disciplines: 900::Fisheries science: 920 teleost biology biology.organism_classification Acquired immune system 030104 developmental biology medicine.anatomical_structure antibody secreting cells peritoneal cavity biology.protein lcsh:RC581-607 030215 immunology |
| Zdroj: | Frontiers in Immunology, Vol 11 (2020) |
| Popis: | B cell responses are a crucial part of the adaptive immune response to viral infection. Infection by salmonid alphavirus subtype 3 (SAV3) causes pancreas disease (PD) in Atlantic salmon (Salmo salar) and is a serious concern to the aquaculture industry. In this study, we have used intraperitoneal (IP) infection with SAV3 as a model to characterize local B cell responses in the peritoneal cavity (PerC) and systemic immune tissues (head kidney/spleen). Intraperitoneal administration of vaccines is common in Atlantic salmon and understanding more about the local PerC B cell response is fundamental. Intraperitoneal SAV3 infection clearly induced PerC B cell responses as assessed by increased frequency of IgM+ B cells and total IgM secreting cells (ASC). These PerC responses were prolonged up to nine weeks post-infection and positively correlated to the anti-SAV3 E2 and to neutralizing antibody responses in serum. For the systemic immune sites, virus-induced changes in B cell responses were more modest or decreased compared to controls in the same period. Collectively, data reported herein indicated that PerC could serve as a peripheral immunological site by providing a niche for prolonged maintenance of the ASC response in Atlantic salmon. |
| Databáze: | OpenAIRE |
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