Narrowing in on cardiovascular disease: the atheroprotective role of peroxisome proliferator-activated receptor gamma
| Autor: | Jon M. Gerry, Gabriel Pascual |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
chemistry.chemical_classification
Inflammation Peroxisome proliferator-activated receptor gamma Macrophages Peroxisome proliferator-activated receptor Receptors Cytoplasmic and Nuclear Biology Macrophage Activation Atherosclerosis Pathogenesis PPAR gamma chemistry Nuclear receptor Immunology Cancer research medicine Humans Peroxisome proliferator-activated receptor alpha medicine.symptom Cardiology and Cardiovascular Medicine Receptor Transrepression Transcription Factors |
| Zdroj: | Trends in cardiovascular medicine. 18(2) |
| ISSN: | 1050-1738 |
| Popis: | Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a nuclear receptor that has been suggested to play protective roles in the pathogenesis of diseases that are characterized by chronic inflammation, such as atherosclerosis. The study of nuclear receptors, including PPAR gamma, has led to the discovery of anti-inflammatory processes that are collectively known as transrepression. In this review, we will highlight some of the mechanisms of PPAR gamma-mediated transrepression that have surfaced throughout the past decade. We will also discuss the existing evidence for an atheroprotective role of PPAR gamma as a repressor of inflammatory genes and as a key determinant of distinct monocyte-derived subpopulations that may serve an anti-inflammatory, homeostatic role in atherogenesis. |
| Databáze: | OpenAIRE |
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