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BACKGROUND: Efficacy of vancomycin in critical ill patients is highly related with adequate vancomycin blood levels, so a vancomycin protocol has been developed in a third-level hospital between the Pharmacy and the Intensive Care Unit (ICU) to achieve this goal. This protocol has been based on therapeutic vancomycin blood levels between 15 and 25 µg/ml, next day of the beginning of the protocol. PURPOSE: To assess if the protocol achieves adequate vancomycin blood levels the next day of the beginning of the loading dose, and propose any measures to improve the protocol. MATERIAL AND METHODS: Prospective and descriptive study from 1 January to 31 May 31 2017, of every patient with vancomycin prescribed in the ICU unit. The patients included were separated by groups into different categories (sex, age, weight, body mass index (BMI), creatinine clearance (CrCl), and pathology). Subsequently, next-day level was analysed, and whether it was between therapeutic range (TR) (15–25 µg/ml) or not. Statistical significance was considered with p80 ml/min, 65% had a level below 15 µg/ml compared to 28.6% in the other groups. CONCLUSION: Because of the results found, at least males and patients with normal creatinine clearance are underdosed, but larger studies must be carried out. The recommendations to improve the protocol are to increase the dose of continuous perfusion in males and patients with CrCl >80 ml/min. No conflict of interest |
