The Effect of Long-Term Heparin Administration on Experimental Liver Fibrosis in Rats
| Autor: | R. Olsson, L. Jordö |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Time Factors Biopsy Liver fibrosis Osteoporosis Hydroxyproline chemistry.chemical_compound Internal medicine medicine Animals Glycosaminoglycans Carbon Tetrachloride Poisoning Heparin business.industry Gastroenterology medicine.disease Rats Endocrinology Liver chemistry Carbon tetrachloride Collagen Chemical and Drug Induced Liver Injury Lysosomes business medicine.drug |
| Zdroj: | Digestion. 7:204-211 |
| ISSN: | 1421-9867 0012-2823 |
| DOI: | 10.1159/000197275 |
| Popis: | Heparin has been shown to increase collagenolytic activity in bone and cause osteoporosis in man. In order to investigate if a similar collagenolytic activity could be induced in the liver and cause a dissolution of liver fibrosis, daily heparin injections were given for 17–20 weeks to rats with CCl4-induced liver fibrosis. No such effect could be demonstrated by means of histological investigation and hydroxyproline determination. Possible reasons for this lack of effect are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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