Can we reduce oxidative stress with liver transplantation?
| Autor: | Mesut Aydin, Yaren Dirik, Harun Egemen Tolunay, Halit Demir, Canan Demir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cirrhosis medicine.medical_treatment Clinical Biochemistry Liver transplantation medicine.disease_cause Superoxide dismutase Lipid peroxidation chemistry.chemical_compound Blood serum Internal medicine oksidativni stres medicine ciroza oxidative stress transplantacija jetre Original Paper biology liver transplantation business.industry cirrhosis Biochemistry (medical) Glutathione medicine.disease Malondialdehyde Endocrinology chemistry biology.protein business Oxidative stress |
| Zdroj: | Journal of Medical Biochemistry |
| ISSN: | 1452-8266 1452-8258 |
| Popis: | The aim of this study was to determine the levels of lipid peroxidation (MDA) and antioxidants such as reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in the blood serum of patients with cirrhosis and liver transplantation.In this study, serum malondialdehyde acid (MDA) levels, superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) activities were measured spectrophotometrically and compared to the results of the healthy control group.SOD, CAT and GSH activities were significantly decreased in the patient groups compared to the healthy control group (p0.05). MDA levels were significantly higher in the patient group compared to the healthy control group (p0.05).In conclusion, this study demonstrated that oxidative stress may play an important role in the development of liver cirrhosis and in liver transplantation. This study is the first one to show how MDA, SOD, CAT and GSH levels change in liver cirrhosis and liver transplantation, while further studies are essential to investigate antioxidant enzymes and oxidative stress status in patients with cirrhosis and liver transplantation.Cilj ovog rada je bio da se odrede nivoi lipidne peroksidacije (MDA) i antioksidanti kao što su redukovani glutation (GSH), katalaza (CAT) i superoksid dismutaza (SOD) u krvi seruma pacijenata sa cirozom i transplantacijom jetre.U ovom izučavanju nivoi serumskog malondialdehida (MDA), superoksid dismutaze (SOD), redukovanog glutationa (GSH) i aktivnost katalaze (CAT) mereni su spektrofotometrijski i pore|eni sa rezultatima dobijenim kod zdrave kontrolne grupe.Vrednosti SOD, CAT i GSH bile su značajno niže u grupi zdravih (p0,05). Nivoi MDA bili su značajno viši u grupi pacijenata u odnosu na grupu zdravih osoba (p0,05).Na osnovu ovog izučavanja može se zaključiti da oksidativni stres ima značajnu ulogu u razvoju ciroze i transplantacije jetre. Ovo je prvo izučavanje koje ukazuje kako se nivoi MDA, SOD, CAT i GSH menjaju u cirozi jetre i transplantaciji jetre. Sledeća izučavanja biće značajna za proučavanje antioksidativnih enzima i statusa oksidativnog stresa u pacijenata sa cirozom i transplantacijom jetre. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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