CMV and Immunosenescence: from basics to clinics

Autor: Jerrald L. Rector, René A. W. van Lier, Florian Kern, Sara Cantisán, Andrea B. Maier, Miguel López-Botet, Carmen Campos, Elissaveta Naumova, Tamas Fulop, Daniela Frasca, Delphine Sauce, Natalie E. Riddell, Anis Larbi, Beatriz Sanchez-Correa, Maciej Zieliński, Mark R. Wills, Allison E. Aiello, Jos A. Bosch, Arne N. Akbar, Raquel Tarazona, Janet E. McElhaney, Janko Nikolich-Zugich, Paolo Sansoni, Sara Ferrando-Martinez, Victor Appay, Mark Beswick, Sheila Govind, Graham Pawelec, Evelyna Derhovanessian, George C. Wang, Mikko Hurme, Ann B. Hill, Paul Moss, Beatrix Grubeck-Loebenstein, Alejandra Pera, Rafael Solana, Luka Cicin-Sain
Přispěvatelé: Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)-Reina Sofia University-Hospital-University of Cordoba, University of Extremadura, University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Division of Infection and Immunity, University College of London [London] (UCL), International Research Center of Medical Sciences (IRCMS), Kumamoto University, Cancer Sciences School, University of Birmingham [Birmingham], Advisory Board of OA Cancer, University of Amsterdam [Amsterdam] (UvA), Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Department of Internal Medicine II, Eberhard Karls Universität Tübingen = Eberhard Karls University of Tuebingen-Center for Medical Research, Laboratory of Molecular Immune-Biology, Hospital General Universitario Gregorio Marañón, Department of Microbiology and Immunology, University of Miami Leonard M. Miller School of Medicine (UMMSM), Semmelweis University [Budapest, Hungary], Regenerative Medicine Group, Cranfield University-Cranfield Health, Institute for Biomedical Aging Research, University of Innsbruck, Department of Molecular Microbiology and Immunology, Oregon Health and Science University [Portland] (OHSU), Medical School, University of Tampere [Finland], Brighton and Sussex Medical School (BSMS), Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Hospital del Mar Medical Research Institute (IMIM), Universitat Pompeu Fabra [Barcelona] (UPF), Health Sciences North Research Institute [Sudbury], Department of Clinical Immunology, University Hospital Alexandrovska, Department of Immunobiology, University of Arizona-College of Medicine, School of Sport and Exercise Sciences, Department of Internal Medicine, University of Parma = Università degli studi di Parma [Parme, Italie], Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Experimental Immunology, Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), Division of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Department of Medicine, University of Cambridge [UK] (CAM)-Addenbrooke's Hospital, Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Section for Transplantation Immunology and Immunohaematology, University Hospital Tübingen, Universidad de Extremadura - University of Extremadura (UEX), Department of Epidemiology, University of Michigan [Ann Arbor], University of Michigan System-University of Michigan System-Center for Social Epidemiology and Population Health, Immunité et Infection, Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Mannheim Institute of Public Health, Social and Preventive Medicine (MIPH), Universität Heidelberg [Heidelberg]-Mannheim Medical Faculty, Research Center on Aging (CDRV), Université de Sherbrooke (UdeS)-Institut Universitaire de Gériatrie de Sherbrooke (CSSS-IUGS)-Centre de Santé et de Services Sociaux, Leopold Franzens Universität Innsbruck - University of Innsbruck, Immunology, Department of Health and Experimental Sciences (DCEXS), Universitat Pompeu Fabra [Barcelona] (UPF)-Hospital del Mar Research Institute (IMIM), Department of Gerontology and Geriatrics, Leiden University Medical Center (LUMC), Division of Geriatric Medicine, University of British Columbia (UBC), Department of Internal Medicine and Biomedical Sciences, Università degli studi di Parma = University of Parma (UNIPR), Johns Hopkins University School of Medicine-Biology of Healthy Aging Program, The Workshop was partially supported by the University of Cordoba and the Spanish Ministry of Science (SAF2011-16169-E)., BMC, Ed., Universität Heidelberg [Heidelberg] = Heidelberg University-Mannheim Medical Faculty, Universiteit Leiden-Universiteit Leiden, Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany., Neuromechanics, AMS - Ageing and Morbidity, Klinische Psychologie (Psychologie, FMG), Wills, Mark [0000-0001-8548-5729], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2012
Předmět:
lcsh:Immunologic diseases. Allergy
Aging
Biomedical
[SDV.IMM] Life Sciences [q-bio]/Immunology
[SDV]Life Sciences [q-bio]
Immunology
education
Review
lcsh:Geriatrics
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Immune system
Immunitat cel·lular
SDG 3 - Good Health and Well-being
medicine
2.1 Biological and endogenous factors
Inflammatory and Immune System
ComputingMilieux_MISCELLANEOUS
030304 developmental biology
0303 health sciences
Innate immune system
biology
business.industry
Geriatrics gerontology
4. Education
virus diseases
Cytomegalovirus
Immunosenescence
Acquired immune system
3. Good health
Ageing
lcsh:RC952-954.6
Infectious Diseases
1107 Immunology
biology.protein
[SDV.IMM]Life Sciences [q-bio]/Immunology
Immunization
Antibody
Infection
business
lcsh:RC581-607
030215 immunology
Zdroj: Immunity & Ageing
Immunity & Ageing, 2012, 9 (1), ⟨10.1186/1742-4933-9-23⟩
Immunity & Ageing, Vol 9, Iss 1, p 23 (2012)
Immunity & Ageing : I & A
Immunity & Ageing, 2012, 9 (1), pp.23. ⟨10.1186/1742-4933-9-23⟩
Recercat. Dipósit de la Recerca de Catalunya
instname
Immunity and Ageing, 9(1), 23
Solana, R, Tarazona, R, Aiello, A E, Akbar, A N, Appay, V, Beswick, M, Bosch, J A, Campos, C, Cantisán, S, Cicin-Sain, L, Derhovanessian, E, Ferrando-Martínez, S, Frasca, D, Fulöp, T, Govind, S, Grubeck-Loebenstein, B, Hill, A, Hurme, M, Kern, F, Larbi, A, López-Botet, M, Maier, A B, McElhaney, J E, Moss, P, Naumova, E, Nikolich-Zugich, J, Pera, A, Rector, J L, Riddell, N, Sanchez-Correa, B, Sansoni, P, Sauce, D, van Lier, R, Wang, G C, Wills, M R, Zieliński, M & Pawelec, G 2012, ' CMV and Immunosenescence : From basics to clinics ', Immunity and Ageing, vol. 9, 23, pp. 1-9 . https://doi.org/10.1186/1742-4933-9-23
Immunity and Ageing, 9:23, 1-9. BioMed Central
Immunity and Ageing
Immunity & Ageing, 9. BioMed Central
ISSN: 1742-4933
DOI: 10.1186/1742-4933-9-23⟩
Popis: Alone among herpesviruses, persistent Cytomegalovirus (CMV) markedly alters the numbers and proportions of peripheral immune cells in infected-vs-uninfected people. Because the rate of CMV infection increases with age in most countries, it has been suggested that it drives or at least exacerbates “immunosenescence”. This contention remains controversial and was the primary subject of the Third International Workshop on CMV & Immunosenescence which was held in Cordoba, Spain, 15-16th March, 2012. Discussions focused on several main themes including the effects of CMV on adaptive immunity and immunosenescence, characterization of CMV-specific T cells, impact of CMV infection and ageing on innate immunity, and finally, most important, the clinical implications of immunosenescence and CMV infection. Here we summarize the major findings of this workshop. The Workshop was partially supported by the University of Cordoba and the Spanish Ministry of Science (SAF2011-16169-E)
Databáze: OpenAIRE
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